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题名: Sophoridine from Sophora Flower Attenuates Ovariectomy Induced Osteoporosis through the RANKL-ERK-NFAT Pathway
作者: Zhao, Xiaoying2, 3, 4; Mei, Lijuan1; Pei, Jinjin1, 5; Liu, Zenggen1; Shao, Yun1; Tao, Yanduo1; Zhang, Xiaoling2, 3, 4; Jiang, Lei1
刊名: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期: 2017-11-08
卷号: 65, 期号:44, 页码:9647-9654
关键词: osteoporosis ; sophora flower ; sophoridine ; osteoclast differentiation ; MAPK ; NFATc1
DOI: 10.1021/acs.jafc.7b03666
文章类型: Article
英文摘要: An imbalance in osteogenesis and osteoclastogenesis is a crucial pathological factor in the development of osteoporosis. Osteoclasts (OCs) play a pivotal role in osteoporosis, whose new therapy exploration has been focused on the suppression of OC formation. Sophoridine is found from the Chinese traditional food sophora flower to exhibit anti-osteoporosis capacity by screening. This study is focused on its anti -osteoporosis mechanism evaluation. The anti -osteoporosis effect of sophoridine, (15 mg kg(-1) body), was evaluated in ovariectomized (OVX) mice by monitoring changes in bone histomorphometry index, formation of osteoclasts from blood-derived mononuclear cells, and changes in the synthesis of pro-osteodastogenic cytokines. Signal pathways were investigated by QPCR, Western blot, and immunofluorescence. Sophoridine has a significant anti-osteoporosis effect in vivo, which can inhibit RANKL-induced OC formation, the appearance of OC-specific marker genes, and OC marker protein in vitro. Mechanistically, sophoridine dose- and time-dependently blocks the RANKL-induced OC formation and the activation of ERK and c-Fos as well as the induction and nucleus translocation of NFATc1. Sophora flower might be a useful alternative functional food in preventing or treating osteoporosis.
WOS标题词: Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]: Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]: Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]: BONE LOSS ; AGENTS
收录类别: SCI
项目资助者: Natural Science Foundation of Qinghai(2016-ZJ-942Q) ; West Light Foundation of the Chinese Academy of Sciences(Y629071211) ; National Natural Science Foundation of China(81572123 ; Science and Technology Commission of Shanghai Municipality(14431900900 ; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support(20161314) ; 31701243) ; 115411951100 ; 116430723500)
语种: 英语
WOS记录号: WOS:000415028700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://210.75.249.4/handle/363003/10360
Appears in Collections:中国科学院西北高原生物研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Northwest Plateau Inst Biol, Key Lab Tibetan Med Res, Xining 810001, Qinghai, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200025, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200025, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Dept Orthoped Surg, Shanghai 200092, Peoples R China
5.Shaanxi Univ Technol, Shaanxi Key Lab Bioresources & Biol, Hanzhong 723001, Peoples R China
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