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Selective and sensitive detection of Zn(II) ion using a simple peptide-based sensor
Wan, Jiajia1; Duan, Wenxiu1; Chen, Kai1; Tao, Yanduo2; Dang, Jun2; Zeng, Kehao3; Ge, Yushu1; Wu, Jiang3; Liu, Dan1
2018-02-01
发表期刊SENSORS AND ACTUATORS B-CHEMICAL
卷号255页码:49-56
文章类型Article
摘要The development of biocompatible chemosensors is becoming increasingly important for chemical analyses in environmental sampling, the food industry, and clinical medicine. Many current chemosensors have limited utility as they represent potential secondary pollutants. To circumvent this problem, researchers are evaluating peptide-based fluorescent chemosensors because of their well-established synthesis protocols, good biological compatibility, and generally low cytotoxicity, which makes them suitable for bioimaging. In this study, we report the development of a peptide-based fluorescent chemosensor HL (fluorophore-Cys-Pro-Gly-His) for divalent zinc ions (Zn2+). The objective of this study was to select a suitable peptide sequence and associated fluorophore exhibiting high selectivity and sensitivity to Zn2+-binding, and enhanced fluorescent response. Results of this study, both in vitro and in living cells, indicated that HL exhibited high selectivity and sensitivity for Zn2+, with a limit of detection (LOD) of about 82 nM. The sensor also exhibited very low cell cytotoxicity and strong fluorescence emission in living cells, which indicates that it may find application as a novel chemosensor for selective Zn2+ detection in biological environments. (C) 2017 Elsevier B.V. All rights reserved.
关键词Peptide-based Sensor Zinc Ion detectIon Fluorescence Emission Bio-imaging
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1016/j.snb.2017.08.038
关键词[WOS]ON FLUORESCENT CHEMOSENSOR ; CELL BIOLOGY ; METAL-IONS ; ZINC IONS ; SPECTROMETRY ; ACTIVATION ; BIOSENSORS ; SYSTEMS ; DESIGN ; ZN2+
收录类别SCI
语种英语
项目资助者Recruitment Program for Young Professionals(KJ2070000027) ; Major State Special Research Project of China(2016YFA0101200) ; Independent Innovation Foundation of University of Science and Technology of China(WK2070000037) ; Major State Basic Research Development Program of China (973 Program)(2015CB553701) ; National Natural Science Foundation of China(21201091) ; Fundamental Research Funds for the Central Universities(lzujbky-2013-59)
WOS研究方向Chemistry ; Electrochemistry ; Instruments & Instrumentation
WOS类目Chemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS记录号WOS:000414151800007
引用统计
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/10364
专题中国科学院西北高原生物研究所
作者单位1.Univ Sci & Technol China, Sch Life Sci, Collaborat Innovat Ctr Chem Life Sci, Hefei 230027, Anhui, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
3.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
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Wan, Jiajia,Duan, Wenxiu,Chen, Kai,et al. Selective and sensitive detection of Zn(II) ion using a simple peptide-based sensor[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018,255:49-56.
APA Wan, Jiajia.,Duan, Wenxiu.,Chen, Kai.,Tao, Yanduo.,Dang, Jun.,...&Liu, Dan.(2018).Selective and sensitive detection of Zn(II) ion using a simple peptide-based sensor.SENSORS AND ACTUATORS B-CHEMICAL,255,49-56.
MLA Wan, Jiajia,et al."Selective and sensitive detection of Zn(II) ion using a simple peptide-based sensor".SENSORS AND ACTUATORS B-CHEMICAL 255(2018):49-56.
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