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题名: Selective and sensitive detection of Zn(II) ion using a simple peptide-based sensor
作者: Wan, Jiajia1; Duan, Wenxiu1; Chen, Kai1; Tao, Yanduo2; Dang, Jun2; Zeng, Kehao3; Ge, Yushu1; Wu, Jiang3; Liu, Dan1
刊名: SENSORS AND ACTUATORS B-CHEMICAL
出版日期: 2018-02-01
卷号: 255, 页码:49-56
关键词: Peptide-based sensor ; Zinc ion detection ; Fluorescence emission ; Bio-imaging
DOI: 10.1016/j.snb.2017.08.038
文章类型: Article
英文摘要: The development of biocompatible chemosensors is becoming increasingly important for chemical analyses in environmental sampling, the food industry, and clinical medicine. Many current chemosensors have limited utility as they represent potential secondary pollutants. To circumvent this problem, researchers are evaluating peptide-based fluorescent chemosensors because of their well-established synthesis protocols, good biological compatibility, and generally low cytotoxicity, which makes them suitable for bioimaging. In this study, we report the development of a peptide-based fluorescent chemosensor HL (fluorophore-Cys-Pro-Gly-His) for divalent zinc ions (Zn2+). The objective of this study was to select a suitable peptide sequence and associated fluorophore exhibiting high selectivity and sensitivity to Zn2+-binding, and enhanced fluorescent response. Results of this study, both in vitro and in living cells, indicated that HL exhibited high selectivity and sensitivity for Zn2+, with a limit of detection (LOD) of about 82 nM. The sensor also exhibited very low cell cytotoxicity and strong fluorescence emission in living cells, which indicates that it may find application as a novel chemosensor for selective Zn2+ detection in biological environments. (C) 2017 Elsevier B.V. All rights reserved.
WOS标题词: Science & Technology ; Physical Sciences ; Technology
类目[WOS]: Chemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
研究领域[WOS]: Chemistry ; Electrochemistry ; Instruments & Instrumentation
关键词[WOS]: ON FLUORESCENT CHEMOSENSOR ; CELL BIOLOGY ; METAL-IONS ; ZINC IONS ; SPECTROMETRY ; ACTIVATION ; BIOSENSORS ; SYSTEMS ; DESIGN ; ZN2+
收录类别: SCI
项目资助者: Recruitment Program for Young Professionals(KJ2070000027) ; Major State Special Research Project of China(2016YFA0101200) ; Independent Innovation Foundation of University of Science and Technology of China(WK2070000037) ; Major State Basic Research Development Program of China (973 Program)(2015CB553701) ; National Natural Science Foundation of China(21201091) ; Fundamental Research Funds for the Central Universities(lzujbky-2013-59)
语种: 英语
WOS记录号: WOS:000414151800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://210.75.249.4/handle/363003/10364
Appears in Collections:中国科学院西北高原生物研究所_期刊论文

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作者单位: 1.Univ Sci & Technol China, Sch Life Sci, Collaborat Innovat Ctr Chem Life Sci, Hefei 230027, Anhui, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
3.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
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