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H5N1 avian influenza re-emergence of Lake Communication Qinghai: phylogenetic and antigenic analyses of the newly isolated viruses and roles of migratory birds in virus circulation
Wang, Guihua2,3,4,5; Zhan, Dawei6,7; Li, Laixing8; Lei, Fumin9; Liu, Bohua6,7; Liu, Di2,3,4,5; Xiao, Haixia2,3,4,5; Feng, Youjun2,3,4,5; Li, Jing6,7; Yang, Baoan6,7; Yin, Zuohua9; Song, Xiaohui2,3,4,5; Zhu, Xiaojia4; Cong, Yanlong1; Pu, Juan1; Wang, Jian10; Liu, Jinhua1; Gao, George F.2,3,5; Zhu, Qingyu6,7
2008-03-01
Source PublicationJOURNAL OF GENERAL VIROLOGY
Volume89Issue:marchPages:697-702
SubtypeArticle
AbstractHighly pathogenic avian influenza H5N1 virus has swept west across the globe and caused serious debates on the roles of migratory birds in virus circulation since the first large-scale outbreak in migratory birds of Lake Qinghai, 2005. In May 2006, another outbreak struck Lake Qinghai and six novel strains were isolated. To elucidate these QH06 viruses, the six isolates were subjected to whole-genome sequencing. Phylogenetic analyses show that QH06 viruses are derived from the lineages of Lake Qinghai, 2005. Five of the six novel isolates are adjacent to the strain A/Cygnus olor/Croatia/1/05, and the last one is related to the strain A/duck/Novosibirsk/ 02/05, an isolate of the flyway. Antigenic analyses suggest that QH06 and QH05 viruses are similar to each other. These findings implicate that QH06 viruses of Lake Qinghai may travel back via migratory birds, though not ruling out the possibility of local circulation of viruses of Lake Qinghai.; Highly pathogenic avian influenza H5N1 virus has swept west across the globe and caused serious debates on the roles of migratory birds in virus circulation since the first large-scale outbreak in migratory birds of Lake Qinghai, 2005. In May 2006, another outbreak struck Lake Qinghai and six novel strains were isolated. To elucidate these QH06 viruses, the six isolates were subjected to whole-genome sequencing. Phylogenetic analyses show that QH06 viruses are derived from the lineages of Lake Qinghai, 2005. Five of the six novel isolates are adjacent to the strain A/Cygnus olor/Croatia/1/05, and the last one is related to the strain A/duck/Novosibirsk/ 02/05, an isolate of the flyway. Antigenic analyses suggest that QH06 and QH05 viruses are similar to each other. These findings implicate that QH06 viruses of Lake Qinghai may travel back via migratory birds, though not ruling out the possibility of local circulation of viruses of Lake Qinghai.
Keyworda Virus Sequence Alignment Pb1-f2 Protein Evolution Waterfowl China Outbreak Spread Hosts Flu
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Subject Area微生物学
WOS KeywordA VIRUS ; SEQUENCE ALIGNMENT ; PB1-F2 PROTEIN ; EVOLUTION ; WATERFOWL ; CHINA ; OUTBREAK ; SPREAD ; HOSTS ; FLU
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Virology
WOS SubjectBiotechnology & Applied Microbiology ; Virology
WOS IDWOS:000253998700010
Citation statistics
Cited Times:87[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/1228
Collection中国科学院西北高原生物研究所
Affiliation1.China Agr Univ, Coll Vet Med, Beijing 100094, Peoples R China
2.Chinese Acad Sci, Inst Microbiol, Ctr Mol Virol, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Microbiol, Ctr Mol Immunol, Beijing 100101, Peoples R China
4.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Inst Microbiol, China Japan Joint Lab Mol Immunol & Mol Microbiol, Beijing 100080, Peoples R China
6.Acad Mil Med Sci, State Key Lab Pathogens & Biosecur, Beijing 100071, Peoples R China
7.Acad Mil Med Sci, Inst Microbiol & Epidemiol, Beijing 100071, Peoples R China
8.Chinese Acad Sci, NW Inst Plateau Biol, Xining 810008, Peoples R China
9.Chinese Acad Sci, Inst Zool, Beijing 100080, Peoples R China
10.Chinese Acad Sci, Beijing Genom Inst, Beijing 101300, Peoples R China
Recommended Citation
GB/T 7714
Wang, Guihua,Zhan, Dawei,Li, Laixing,et al. H5N1 avian influenza re-emergence of Lake Communication Qinghai: phylogenetic and antigenic analyses of the newly isolated viruses and roles of migratory birds in virus circulation[J]. JOURNAL OF GENERAL VIROLOGY,2008,89(march):697-702.
APA Wang, Guihua.,Zhan, Dawei.,Li, Laixing.,Lei, Fumin.,Liu, Bohua.,...&Zhu, Qingyu.(2008).H5N1 avian influenza re-emergence of Lake Communication Qinghai: phylogenetic and antigenic analyses of the newly isolated viruses and roles of migratory birds in virus circulation.JOURNAL OF GENERAL VIROLOGY,89(march),697-702.
MLA Wang, Guihua,et al."H5N1 avian influenza re-emergence of Lake Communication Qinghai: phylogenetic and antigenic analyses of the newly isolated viruses and roles of migratory birds in virus circulation".JOURNAL OF GENERAL VIROLOGY 89.march(2008):697-702.
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