EFFECT OF ARGIPRESSIN AND ITS RELATED-COMPOUNDS ON CORTICOTROPIN RELEASING HORMONE CONTENTS IN HYPOTHALAMUS OF RATS

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	EFFECT OF ARGIPRESSIN AND ITS RELATED-COMPOUNDS ON CORTICOTROPIN RELEASING HORMONE CONTENTS IN HYPOTHALAMUS OF RATS
	YOU, ZB; DU, JZ
	1991-03-01
发表期刊	ACTA PHARMACOLOGICA SINICA
ISSN	0253-9756
卷号	12 期号:2 页码:164-166
文章类型	Article
摘要	The paper mainly stresses on the effect of argipressin (Arg), 2-destyrosyl-3-desphenyl-alanyl-9-desglycyl-9-desglycyl-amide-Arg (Arg4-8), [1-deaminopenicillamine, 2-(o-methyl)tyrosine]-Arg (DPArg) and Arg antiserum on corticotropin releasing hormone (CRH) contents in median eminence (ME) and the level of plasma corticosterone after injected into the third ventricle of rats. The results show: 1) the CRH contents in ME significantly reduced with icv 100, 200, and 800 ng of Arg; 2) 100 ng of Arg4-8 and Arg antiserum (2-mu-l, 1:1 diluted with 0.9% saline) increased CRH contents in ME and enhanced plasma corticosterone; 3) DPArg had no effect on CRH level but blocked the inhibitory role of Arg on central CRH. These results suggest that Arg acts as an inhibitory factor in regulating central CRH level and V1 receptor is involved.
关键词	Argipressin Peptides Corticotropin Releasing Hormone Corticosterone Median Eminence
WOS标题词	Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
关键词[WOS]	ARGININE VASOPRESSIN ; SECRETION ; CATECHOLAMINES ; NEURONS ; CELLS
收录类别	SCI
语种	英语
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS类目	Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS记录号	WOS:A1991FB87500015
出版者	ACTA PHARMACOLOGICA SINICA
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/13267
专题	中国科学院西北高原生物研究所
通讯作者	YOU, ZB
推荐引用方式 GB/T 7714	YOU, ZB,DU, JZ. EFFECT OF ARGIPRESSIN AND ITS RELATED-COMPOUNDS ON CORTICOTROPIN RELEASING HORMONE CONTENTS IN HYPOTHALAMUS OF RATS[J]. ACTA PHARMACOLOGICA SINICA,1991,12(2):164-166.
APA	YOU, ZB,&DU, JZ.(1991).EFFECT OF ARGIPRESSIN AND ITS RELATED-COMPOUNDS ON CORTICOTROPIN RELEASING HORMONE CONTENTS IN HYPOTHALAMUS OF RATS.ACTA PHARMACOLOGICA SINICA,12(2),164-166.
MLA	YOU, ZB,et al."EFFECT OF ARGIPRESSIN AND ITS RELATED-COMPOUNDS ON CORTICOTROPIN RELEASING HORMONE CONTENTS IN HYPOTHALAMUS OF RATS".ACTA PHARMACOLOGICA SINICA 12.2(1991):164-166.