Hypoxia effects on hypothalamic corticotropin-releasing hormone and anterior pituitary cAMP

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	Hypoxia effects on hypothalamic corticotropin-releasing hormone and anterior pituitary cAMP
	Chen, Z; Du, JZ
	1996-11-01
发表期刊	ACTA PHARMACOLOGICA SINICA
ISSN	0253-9756
卷号	17 期号:6 页码:489-492
文章类型	Article
摘要	AIM: To study the effects of acute and chronic hypoxia on hypothalamus-anterior pituitary-adrenocortex axis. METHODS: Rats and pikas were exposed to different altitude and periods. Animals were injected with CRH, Arg and NE in the third ventricle of the brain of rats. RESULTS: Anterior pituitary cAMP and plasma corticosterone levels of rats obviously increased during 1 h of hypoxia. cAMP was increased from 2.23 +/- 0.13 of control group to 7.7 +/- 0.7 of 5 km and 13.4 +/- 1.9 nmol/g wet tissue of 8 km, respectively. icv CRH, Arg and NE all activated HPA axis. The effects of CRH were most potent. CRH 2 mu L 0.75 nmol icv increased anterior pituitary of cAMP from 3.5 +/- 0.4 of control to 22.4 +/- 2.2 nmol/kg wet tissue. Stimulating altitude of 5000 m resulted in a 16.9 % decrease in corticosterone level (P < 0.05), 8000 m resulted in a 47.5 % decrease (P < 0.01) after hypoxia for 25 d. Hypoxia did not activate HPA axis in pikas. CONCLUSION: 1) Hypoxia stress activates the secretion of corticotrophin (ACTH) via cAMP; 2) Adrenocotical function of rats decays during chronic hypoxia; 3) Arg and NE regulate the secretion of plasma corticosterone and synthesis of pituitary cAMP at the hypothalamus level; 4) Hypoxia tolerance of the pika was high.
关键词	Sprague-dawley Rats Pikas Anoxia Cyclic Amp Corticosterone Anterior Pituitary Gland Corticotropin-releasing Hormone Argipressin Norepinephrine
WOS标题词	Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
关键词[WOS]	ARGININE VASOPRESSIN ; BETA-ENDORPHIN ; SECRETION ; ADRENOCORTICOTROPIN ; SUBSTANCES ; INVITRO
收录类别	SCI
语种	英语
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS类目	Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS记录号	WOS:A1996VQ48500003
出版者	ACTA PHARMACOLOGICA SINICA
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/13270
专题	中国科学院西北高原生物研究所
通讯作者	Chen, Z
推荐引用方式 GB/T 7714	Chen, Z,Du, JZ. Hypoxia effects on hypothalamic corticotropin-releasing hormone and anterior pituitary cAMP[J]. ACTA PHARMACOLOGICA SINICA,1996,17(6):489-492.
APA	Chen, Z,&Du, JZ.(1996).Hypoxia effects on hypothalamic corticotropin-releasing hormone and anterior pituitary cAMP.ACTA PHARMACOLOGICA SINICA,17(6),489-492.
MLA	Chen, Z,et al."Hypoxia effects on hypothalamic corticotropin-releasing hormone and anterior pituitary cAMP".ACTA PHARMACOLOGICA SINICA 17.6(1996):489-492.