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Anti-proliferative Activities of Two Flavonols with Unsubstituted B-ring from the Leaves of Platanus acerifolia
Chen, Hui-Feng1; Huang, Ri-Zhen1; Zuo, Bo1; Ji, Lan-Ju2; Mo, Zhi-Jian3; Liao, Zhi-Xin1
2017-11-01
发表期刊NATURAL PRODUCT COMMUNICATIONS
ISSN1934-578X
卷号12期号:11页码:1701-1704
文章类型Article
摘要The anti-proliferative activities against five cancer cell lines of two flavonols (1, 2) with unsubstituted B ring isolated from the ethanol extract of the leaves of Platanus acerifolia were investigated. The results showed that compound 1 possessed a noteworthy anti-proliferative activity against MGC-803 cells with an IC50 value of 17.26 +/- 1.04 mu M, and compound 2 was less active than 1 with an IC50 value of 20.29 +/- 1.37 mu M compared with 41.94 +/- 1.58 mu M for the positive control group. In addition, the results of Hoechst 33258 staining, AO/EB staining and annexinV-FITC assays indicated that 1 caused a significant MGC-803 cellular apoptosis in a dose-dependent manner. The further mechanisms showed that compound 1 induced the production of ROS, decreased the mitochondrial membrane potential, and altered pro- and anti-apoptotic proteins, leading to activation of caspase-9 and caspase-3 in the process of cellular apoptosis. The present investigation indicated that compound 1 could be used as a potential anti-cancer candidate.
关键词Platanus Acerifolia Flavonol Anti-proliferative Activity Apoptotic Analysis
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]BUDS ; CELLS
收录类别SCI
语种英语
项目资助者State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University)(CMEMR2016-B06)
WOS研究方向Pharmacology & Pharmacy ; Food Science & Technology
WOS类目Chemistry, Medicinal ; Food Science & Technology
WOS记录号WOS:000417552000009
出版者NATURAL PRODUCTS INC
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/13278
专题中国科学院西北高原生物研究所
通讯作者Liao, Zhi-Xin
作者单位1.Southeast Univ, Dept Pharmaceut Engn, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810008, Qinghai, Peoples R China
3.Jiangsu Jingyuan Biol Engn Co Ltd, Zhenjiang 212100, Peoples R China
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GB/T 7714
Chen, Hui-Feng,Huang, Ri-Zhen,Zuo, Bo,et al. Anti-proliferative Activities of Two Flavonols with Unsubstituted B-ring from the Leaves of Platanus acerifolia[J]. NATURAL PRODUCT COMMUNICATIONS,2017,12(11):1701-1704.
APA Chen, Hui-Feng,Huang, Ri-Zhen,Zuo, Bo,Ji, Lan-Ju,Mo, Zhi-Jian,&Liao, Zhi-Xin.(2017).Anti-proliferative Activities of Two Flavonols with Unsubstituted B-ring from the Leaves of Platanus acerifolia.NATURAL PRODUCT COMMUNICATIONS,12(11),1701-1704.
MLA Chen, Hui-Feng,et al."Anti-proliferative Activities of Two Flavonols with Unsubstituted B-ring from the Leaves of Platanus acerifolia".NATURAL PRODUCT COMMUNICATIONS 12.11(2017):1701-1704.
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