Biosynthetic Mechanism of Luminescent ZnO Nanocrystals in the Mammalian Blood Circulation and Their Functionalization for Tumor Therapy

doi:10.1021/acsami.7b13691

NWIPB OpenIR

	Biosynthetic Mechanism of Luminescent ZnO Nanocrystals in the Mammalian Blood Circulation and Their Functionalization for Tumor Therapy
	Wu, Yi-Zhou 1; Sun, Jie 2,3; Yang, Haowen 4; Zhao, Xiaohui 5; He, Dacheng 6; Pu, Maomao 1; Zhang, Gen 1; He, Nongyue 7; Zeng, Xin 8
	2018-01-10
发表期刊	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
卷号	10 期号:1 页码:105-113
文章类型	Article
摘要	The biosynthesis of nanoparticles in bioreactors using microbial, plant, or animal cells is at the forefront of nanotechnology. We demonstrated for the first time that luminescent, water-soluble ZnO nanocrystals (bio-ZnO NCs) can be spontaneously biosynthesized in the mammalian blood circulation, not in cells, when animals were fed with Zn(CH3COO)(2) aqueous solution. Serum albumin, rather than metallothioneins or glutathione, proved to play the pivotal role in biosynthesis. The bio-ZnO NCs were gradually taken up in the liver and degraded and excreted in the urine. Thus, we propose that in mammals such as rodents, bovinae, and humans, excess metal ions absorbed into the cardiovascular system via the intestine can be transformed into nanoparticles by binding to serum albumin, forming a "provisional metal-pool", to reduce the toxicity of free metal ions at high concentration and regulate metal homeostasis in the body. Furthermore, the bio-ZnO NCs, which showed favorable biocompatibility, were functionalized with the anticancer drug daunorubicin and effectively achieved controlled drug release mediated by intracellular glutathione in tumor xenograft mice.
关键词	Nanocrystal Albumin Biosynthesis Cardiovascular System Mammal
WOS标题词	Science & Technology ; Technology
DOI	10.1021/acsami.7b13691
关键词[WOS]	ZINC-OXIDE NANOPARTICLES ; CELL ; DELIVERY ; ALBUMIN ; METALLOTHIONEIN ; TOXICITY ; COUPLE ; HPLC ; QDS
收录类别	SCI
语种	英语
项目资助者	Jiangsu Provincial Key Research and Development Program(BE2016620) ; Natural Science Foundation of Jiangsu Province(BK20171050) ; Natural Science Foundation of the Jiangsu Higher Education Institutions(17KJB310006) ; Jiangsu Planned Projects for Postdoctoral Research Funds(1601010C) ; Medical Science and Technology Development Foundation of Nanjing Department of Health(JQX15010) ; Nanjing Medical Science and Technique Development Foundation(QRX17072)
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000422814400017
出版者	AMER CHEMICAL SOC
引用统计	被引频次：63[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/13292
专题	中国科学院西北高原生物研究所
通讯作者	Zhang, Gen; He, Nongyue; Zeng, Xin
作者单位	1.Nanjing Med Univ, Sch Basic Med, Dept Cell Biol, Nanjing 211166, Jiangsu, Peoples R China 2.Nanjing Med Univ, Ctr Hygien Anal & Detect, Sch Publ Hlth, Nanjing 211166, Jiangsu, Peoples R China 3.Nanjing Med Univ, Safety Assessment & Res Ctr Drug Pesticide & Vet, Sch Publ Hlth, Nanjing 211166, Jiangsu, Peoples R China 4.ETH, Inst Chem & Bioengn, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland 5.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810001, Qinghai, Peoples R China 6.Beijing Normal Univ, Coll Life Sci, Dept Cell Biol, Beijing 100875, Peoples R China 7.Southeast Univ, Dept Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China 8.Nanjing Med Univ, Obstet & Gynecol Hosp, Nanjing Matern & Child Hlth Med Inst, Nanjing 210004, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Wu, Yi-Zhou,Sun, Jie,Yang, Haowen,et al. Biosynthetic Mechanism of Luminescent ZnO Nanocrystals in the Mammalian Blood Circulation and Their Functionalization for Tumor Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(1):105-113.
APA	Wu, Yi-Zhou.,Sun, Jie.,Yang, Haowen.,Zhao, Xiaohui.,He, Dacheng.,...&Zeng, Xin.(2018).Biosynthetic Mechanism of Luminescent ZnO Nanocrystals in the Mammalian Blood Circulation and Their Functionalization for Tumor Therapy.ACS APPLIED MATERIALS & INTERFACES,10(1),105-113.
MLA	Wu, Yi-Zhou,et al."Biosynthetic Mechanism of Luminescent ZnO Nanocrystals in the Mammalian Blood Circulation and Their Functionalization for Tumor Therapy".ACS APPLIED MATERIALS & INTERFACES 10.1(2018):105-113.