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The chemical speciation, spatial distribution and toxicity of mercury from Tibetan medicine Zuotai, beta-HgS and HgCl2 in mouse kidney
Li, Cen1,3; Xu, Wei2; Chu, Shengqi2; Zheng, Zhiyuan1,3; Xiao, Yuancan1,3; Li, Linshuai1,3; Bi, Hongtai1,3; Wei, Lixin1,3
2018
Source PublicationJOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
ISSN0946-672X
Volume45Pages:104-113
SubtypeArticle
AbstractZuotai, a famous Tibetan medicinal mixture containing beta-HgS, has been used to combine with herbal remedies for treating diseases for more than 1 300 years. The target organ for inorganic mercury toxicity is generally considered to be the kidney. Therefore, it is crucial to reveal the chemical speciation, spatial distribution and potential nephrotoxicity of mercury from Zuotai in kidney. To date, this remains poorly understood. We used Xray absorption spectroscopy (XAS) and micro X-ray fluorescence (mu-XRF) imaging based on synchrotron radiation to study mercury chemical forms and mercury special distribution in kidney after mice were treated orally with Zuotai, beta-HgS or HgCl2. Meanwhile, the histopathology of kidney was observed. Mice exposed with Zuotai showed kidney with significant proportion of mercury ions bound to sulfydryl biomolecules (e.g. Cys-S-lig-S-Cys) plus some of unknown species, but without methylmercury cysteine, which is the same as beta-HgS and HgCl2. The mercury is mainly deposited in renal cortex in mouse treated with Zuotai, beta-HgS or HgCl2, but with a low level of mercury in medulla. The total mercury in kidney of mice treated with HgCl2 was much higher than that of beta-HgS, and the later was higher than that of Zuotai. And, HgCl2 cause severe impairments in mouse kidney, but that was not observed in the Zuotai and beta-HgS groups. Meanwhile, the bio-metals (Ca, Zn, Fe and Cu) micro distributions in kidney were also revealed. These findings elucidated the chemical nature, spatial distribution and toxicity difference of mercury from Zuotai, beta-HgS and HgCl2 in mouse kidney, and provide new insights into the appropriate methods for biological monitoring.
KeywordTibetan Medicine Zuotai Mercury X-ray Absorption Spectroscopy Micro X-ray Fluorescence Imaging Chemical Forms Nephrotoxicity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.jtemb.2017.08.010
WOS KeywordFRESH-WATER SEDIMENTS ; INORGANIC MERCURY ; GENE-EXPRESSION ; MICE ; CHLORIDE ; METHYLMERCURY ; GLUTATHIONE ; LIVER ; ACCUMULATION ; SPECTROMETRY
Indexed BySCI
Language英语
Funding Organization"The Dawn of West China" Talent Training Program of Chinese Academy of Sciences(Y529021211) ; Science Foundation for Young Scholars of Qinghai Province(2016-ZJ-919Q) ; National Natural Science Foundation of China(81374063) ; Development Program of Key Laboratory in Qinghai Province(2017-ZJ-Y08)
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000419812800015
PublisherELSEVIER GMBH, URBAN & FISCHER VERLAG
Citation statistics
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/13303
Collection中国科学院西北高原生物研究所
Corresponding AuthorWei, Lixin
Affiliation1.Chinese Acad Sci, Northwest Inst Plateau Biol, Pharmacol & Safety Evaluat Key Lab Tibetan Med Qi, Xining 810008, Qinghai, Peoples R China
2.Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
Recommended Citation
GB/T 7714
Li, Cen,Xu, Wei,Chu, Shengqi,et al. The chemical speciation, spatial distribution and toxicity of mercury from Tibetan medicine Zuotai, beta-HgS and HgCl2 in mouse kidney[J]. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,2018,45:104-113.
APA Li, Cen.,Xu, Wei.,Chu, Shengqi.,Zheng, Zhiyuan.,Xiao, Yuancan.,...&Wei, Lixin.(2018).The chemical speciation, spatial distribution and toxicity of mercury from Tibetan medicine Zuotai, beta-HgS and HgCl2 in mouse kidney.JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,45,104-113.
MLA Li, Cen,et al."The chemical speciation, spatial distribution and toxicity of mercury from Tibetan medicine Zuotai, beta-HgS and HgCl2 in mouse kidney".JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY 45(2018):104-113.
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