NWIPB OpenIR
The CXCL12-CXCR4 signaling promotes oocyte maturation by regulating cumulus expansion in sheep
Zhang, Rui-Na1; Pang, Bo1; Xu, Shang-Rong2; Wan, Peng-Cheng3; Guo, Song-Chang1; Ji, Han-Zhong4; Jia, Gong-Xue1; Hu, Lin-Yong1; Zhao, Xin-Quan1; Yang, Qi-En1,5
2018-02-01
Source PublicationTHERIOGENOLOGY
ISSN0093-691X
Volume107Pages:85-94
SubtypeArticle
AbstractGonadotropins and growth factors synergistically regulate folliculogenesis and oocyte development. C-XC motif chemokine 12 (CXCL12) and its receptor CXCR4 are expressed in ovaries of sheep, cattle and other species, however, roles of this multifunctional signal axis in oocyte maturation are not defined. Using sheep as a model, we examined the expression patterns and functions of the CXCL12-CXCR4 axis during oocyte maturation. CXCL12 and CXCR4 mRNA and protein were present in oocytes and granulosa cells. Relative abundance of CXCR4 transcript was controlled by epidermal growth factor (EGF). Transient inhibition of CXCR4 suppressed oocyte nuclear maturation while supplementing recombination CXCL12 significantly increased percent of oocyte undergone metaphase I phase. Inhibition of CXCR4 function decreased cumulus expansion growth rate. Furthermore, granulosa cell migration was impaired and expression of hyaluronan synthase 2 (HAS2) and hyaluronan binding protein tumor necrosis factor alpha-induced protein 6 (TNFAIP6) were downregulated by CXCR4 inhibition. These findings revealed a novel role of the CXCL12-CXCR4 signaling in oocyte development in sheep. (C) 2017 Elsevier Inc. All rights reserved.
KeywordSheep Ovary Cxcl12 Cxcr4 Oocyte In Vitro Maturation
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.theriogenology.2017.10.039
WOS KeywordGROWTH-FACTOR RECEPTOR ; FOLLICLE-STIMULATING-HORMONE ; HYALURONIC-ACID SYNTHESIS ; FACTOR-I ; DEVELOPMENTAL COMPETENCE ; PREOVULATORY FOLLICLES ; OVARIAN-FOLLICLE ; CYTOPLASMIC MATURATION ; CXCR4 ; MOUSE
Indexed BySCI
Language英语
Funding OrganizationNational Key Research & Development Project(2016YFC0501805) ; Qinghai Department of Science and Technology(2015-ZJ-714 ; CAS "100 Talents" program ; Qinghai "1000 Talents" program ; CPSF-CAS ; CAS "Light of West China Foundation" ; 2016-ZJ-917Q)
WOS Research AreaReproductive Biology ; Veterinary Sciences
WOS SubjectReproductive Biology ; Veterinary Sciences
WOS IDWOS:000422892800012
PublisherELSEVIER SCIENCE INC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/13311
Collection中国科学院西北高原生物研究所
Corresponding AuthorZhao, Xin-Quan; Yang, Qi-En
Affiliation1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Evolut & Adaptat Plateau Biota, Xining 810008, Qinghai, Peoples R China
2.Qinghai Univ, Qinghai Acad Anim Sci & Vet Med, Xining 810016, Qinghai, Peoples R China
3.Xinjiang Acad Agr & Reclamat Sci, Anim Husb & Vet Inst, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832003, Peoples R China
4.Haibei Inst Anim Husb & Vet Sci, Haibei 810299, Tibetan Autonom, Peoples R China
5.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Ecol Genom, Xining 810008, Qinghai, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Rui-Na,Pang, Bo,Xu, Shang-Rong,et al. The CXCL12-CXCR4 signaling promotes oocyte maturation by regulating cumulus expansion in sheep[J]. THERIOGENOLOGY,2018,107:85-94.
APA Zhang, Rui-Na.,Pang, Bo.,Xu, Shang-Rong.,Wan, Peng-Cheng.,Guo, Song-Chang.,...&Yang, Qi-En.(2018).The CXCL12-CXCR4 signaling promotes oocyte maturation by regulating cumulus expansion in sheep.THERIOGENOLOGY,107,85-94.
MLA Zhang, Rui-Na,et al."The CXCL12-CXCR4 signaling promotes oocyte maturation by regulating cumulus expansion in sheep".THERIOGENOLOGY 107(2018):85-94.
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