Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice

doi:10.1038/s41598-017-02576-5

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	Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice
	Wang, Hui 1,2; Zhou, Jia 1,2; Liu, Qiong Zhen 3; Wang, Lu Lu 1,2; Shang, Jing 1,2
	2017-05-24
发表期刊	SCIENTIFIC REPORTS
卷号	7
文章类型	Article
摘要	High fat diet (HFD)-induced metabolic disorders may lead to emotional disorders. This study aimed to explore the effect of simvastatin (SMV) and bezafibrate (BZ) on improving HFD-induced emotional changes, and tried to identify their different mechanisms. The intraperitoneal glucose tolerance test (IPGTT) was used to evaluate glucose control ability; and behavior tests including open field tests (OFT), forced swimming tests (FST), tail suspension tests (TST) and sucrose preference (SPT), were then performed to evaluate emotional changes. Serum samples were collected for the LC-MS based metabolomics analysis to explore the emotional-related differential compounds; we then evaluated the effect of the drugs. The abnormal serum metabolic profiling and emotional changes caused by HFD in mice was alleviated by SMV treatment, whereas BZ only affected the emotional disorder. The improvement of cannabinoid analogues and then produced influences on the endocannabinoid system, which may be a potential mechanism SMV action. BZ promoted tryptophan-serotonin pathway and inhibited tryptophan-kynurenine pathway, which may be its mechanism of action. Here, we proposed a shed light on the biological mechanisms underlying the observed effects, and identified an important drug candidate for the treatment of emotional disorders induced by HFD.
WOS标题词	Science & Technology
DOI	10.1038/s41598-017-02576-5
关键词[WOS]	GAMMA PPAR-GAMMA ; AMYOTROPHIC-LATERAL-SCLEROSIS ; UNPREDICTABLE MILD STRESS ; DEPRESSIVE-LIKE BEHAVIOR ; ANXIETY-LIKE BEHAVIOR ; LIQUID-CHROMATOGRAPHY ; ALZHEIMERS-DISEASE ; MASS-SPECTROMETRY ; TRANSGENIC MICE ; ELECTROSPRAY-IONIZATION
收录类别	SCI
语种	英语
项目资助者	Chinese Academy of Sciences ; Applied Basic Research Programs of Qinghai Province(Y229461211) ; Science and Technology Plan Projects in Qinghai Province(2015-ZJ-733) ; Science and Technology Plan Projects in Xinjiang(2014AB043) ; National Found for Fostering Talents of Basic Science (NFFTBS)(J1310032)
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000425910000004
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/13319
专题	中国科学院西北高原生物研究所
作者单位	1.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China 2.China Pharmaceut Univ, Jiangsu Key Lab TCM Evaluat & Translat Res, Nanjing 211198, Jiangsu, Peoples R China 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining 810008, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Wang, Hui,Zhou, Jia,Liu, Qiong Zhen,et al. Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice[J]. SCIENTIFIC REPORTS,2017,7.
APA	Wang, Hui,Zhou, Jia,Liu, Qiong Zhen,Wang, Lu Lu,&Shang, Jing.(2017).Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice.SCIENTIFIC REPORTS,7.
MLA	Wang, Hui,et al."Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice".SCIENTIFIC REPORTS 7(2017).