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Photoinduced electron transfer from polymer-templated Ag nanoclusters to G-quadruplex-hemin complexes for the construction of versatile biosensors and logic gate applications
Qu, Fei1,2; Mao, Beibei1,2,3; Xue, Fangfang1,2; Xia, Lian1,2; You, Jinmao1,2,4; Song, Cuihua1,2
2018-03-01
发表期刊ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷号410期号:8页码:2211-2219
文章类型Article
摘要In this paper, fluorescent Ag nanoclusters (Ag NCs) templated by hyperbranched polyethyleneimine (PEI) are utilized as a versatile probe through the photoinduced electron transfer (PET) between PEI-Ag NCs and G-quadruplex-hemin complexes. In the presence of hemin and target molecule, the specific conjugation with its aptamer induces the conformational change of the DNA sequence, releasing the G-quadruplex sequence part. Once the G-quadruplex-hemin complexes are introduced, electron transfer from the PEI-Ag NCs to G-quadruplex-hemin complexes occurs, resulting in fluorescence quenching. Through changing the sensing DNA sequence, this novel PET system enables the specific detection of target DNA and adenosine triphosphate (ATP) with the wide linear range of 1-200 nM and 5-500 nM, respectively, and the corresponding limit of detection as low as 0.3 nM for target DNA and 1.5 nM for ATP. In addition, the proposed method is successfully applied to the determination of ATP in human serum samples with satisfactory recoveries, and a logic gate is fabricated using target molecules and hemin as inputs and the fluorescence signal of PEI-Ag NCs as an output.
关键词Ag Nanoclusters G-quadruplex-hemin Complexes Adenosine Triphosphate Target Dna Logic Gate
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1007/s00216-018-0887-z
关键词[WOS]LABEL-FREE APTASENSOR ; ZNS QUANTUM DOTS ; SILVER NANOCLUSTERS ; SENSITIVE DETECTION ; SERUM-ALBUMIN ; FLUORESCENCE ; ATP ; PROBES ; SENSOR
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China (Youth Fund Project)(21405093) ; Natural Science Foundation of Shandong Province(ZR2015CM040) ; Scientific Research Foundation of Qufu Normal University(BSQD20130117)
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemical Research Methods ; Chemistry, Analytical
WOS记录号WOS:000426466800015
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/13328
专题中国科学院西北高原生物研究所
作者单位1.Qufu Normal Univ, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China
2.Qufu Normal Univ, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Shandong, Peoples R China
3.Juye Cty Vocat Secondary Sch, Heze 274000, Shandong, Peoples R China
4.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810001, Qinghai, Peoples R China
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Qu, Fei,Mao, Beibei,Xue, Fangfang,et al. Photoinduced electron transfer from polymer-templated Ag nanoclusters to G-quadruplex-hemin complexes for the construction of versatile biosensors and logic gate applications[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2018,410(8):2211-2219.
APA Qu, Fei,Mao, Beibei,Xue, Fangfang,Xia, Lian,You, Jinmao,&Song, Cuihua.(2018).Photoinduced electron transfer from polymer-templated Ag nanoclusters to G-quadruplex-hemin complexes for the construction of versatile biosensors and logic gate applications.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,410(8),2211-2219.
MLA Qu, Fei,et al."Photoinduced electron transfer from polymer-templated Ag nanoclusters to G-quadruplex-hemin complexes for the construction of versatile biosensors and logic gate applications".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 410.8(2018):2211-2219.
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