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A fluorescent sensor for detecting dopamine and tyrosinase activity by dual-emission carbon dots and gold nanoparticles
Qu, Fei1,2; Huang, Wei1,2; You, Jinmao1,2,3
2018-02-01
Source PublicationCOLLOIDS AND SURFACES B-BIOINTERFACES
Volume162Pages:212-219
SubtypeArticle
AbstractIn this work, we report a fluorescence strategy for detecting dopamine (DA) and sensing tyrosinase (TYR) activity on the basis of the dual-emission carbon dots (DECDs), which contain two emitters: the blue emitters (BE, maximum emission at 385 nm) and yellow emitters (YE, maximum emission at 530 nm). Gold nanoparticles (AuNPs) can effectively quench the two emissions of DECDs. The addition of DA aggregates AuNPs effectively, leading to the fluorescence recovery of dual emitters gradually. This strategy exhibits a high selectivity toward DA and shows good linear ranges, such as 0.5-3 mu M for BE and 0.1-3 mu M for YE. Additionally, the proposed method is successfully applied to the determination of DA in real samples with satisfactory recoveries. Subsequently, this DECDs-AuNPs platform is further taken advantage to assess TYR activity by the aid of TYR's capability for oxidation of DA into dopaquinone, which will not induce the agglomeration of AuNPs, so the fluorescence quenching of DECDs is associated with TYR activity. Finally, the mechanism of the reaction is discussed in detail, and the results suggest that both amine and phenolic hydroxyl groups of DA bring the aggregation of AuNPs. (C) 2017 Elsevier B.V. All rights reserved.
KeywordDual-emission Carbon Dots Gold Nanoparticles Dopamine Tyrosinase Activity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology
DOI10.1016/j.colsurfb.2017.11.055
WOS KeywordGRAPHENE QUANTUM DOTS ; NANODOTS ; PROBE ; NANOCLUSTERS ; STRATEGY ; CELLS ; WATER ; ASSAY
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(21405093) ; Scientific Research Foundation of Qufu Normal University(BSQD20130117)
WOS Research AreaBiophysics ; Chemistry ; Materials Science
WOS SubjectBiophysics ; Chemistry, Physical ; Materials Science, Biomaterials
WOS IDWOS:000425076500025
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/13331
Collection中国科学院西北高原生物研究所
Affiliation1.Qufu Normal Univ, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China
2.Qufu Normal Univ, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Shandong, Peoples R China
3.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810001, Qinghai, Peoples R China
Recommended Citation
GB/T 7714
Qu, Fei,Huang, Wei,You, Jinmao. A fluorescent sensor for detecting dopamine and tyrosinase activity by dual-emission carbon dots and gold nanoparticles[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2018,162:212-219.
APA Qu, Fei,Huang, Wei,&You, Jinmao.(2018).A fluorescent sensor for detecting dopamine and tyrosinase activity by dual-emission carbon dots and gold nanoparticles.COLLOIDS AND SURFACES B-BIOINTERFACES,162,212-219.
MLA Qu, Fei,et al."A fluorescent sensor for detecting dopamine and tyrosinase activity by dual-emission carbon dots and gold nanoparticles".COLLOIDS AND SURFACES B-BIOINTERFACES 162(2018):212-219.
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