Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation

doi:10.1016/j.gene.2017.11.070

NWIPB OpenIR

	Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation
	Bao, Qi 1,2,3,5; Li, Chong 4; Xu, Chongfeng 3; Zhang, Ruiying 3; Zhao, Kai 1,2; Duan, Ziyuan 3
	2018-03-10
发表期刊	GENE
卷号	646 页码:47-55
文章类型	Article
摘要	Porcine butyrophilin-like 5 (Btnl5) is a novel member of the butyrophilin family, which consists of immune regulators. The expression pattern and the function of this gene remain unclear. In this study, Btnl5 is identified as a negative regulator of the NF-kappa B pathway. Our study indicates that Btnl5 is mainly expressed in intestinal epithelial cells (IECs) and expressed in membrane systems. Btnl5 inhibits MyD88-mediated activation of the NF-kappa B pathway. Btnl5 interacts with TNF receptor-associated factor 2 (TRAF2) and transcription factor p65. Besides, Btnl5 inhibits p65-mediated activation of the NF-kappa B pathway and inhibits nuclear translocation of p65. These results suggest that Btnl5 may inhibit NF-kappa B pathway through binding and interfere nuclear translocation of p65.
关键词	Btnl5 Iecs Nf-kappa b Immune Regulation Interacting Proteins
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.gene.2017.11.070
关键词[WOS]	ULCERATIVE-COLITIS ; GENE FAMILY ; INFLAMMATION ; ALPHA ; BUTYROPHILINS ; HOMEOSTASIS ; ACTIVATION ; CELLS
收录类别	SCI
语种	英语
项目资助者	National Program on Key Basic Research Project (973 Program)(2013CB835200)
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000425080000007
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/13334
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Qinghai, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Lab Plateau Fish Evolutionary & Funct Genom, Xining 810001, Qinghai, Peoples R China 3.Chinese Acad Sci, Genet Resource Ctr, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Biophys, Core Facil Prot Res, Beijing 100101, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Bao, Qi,Li, Chong,Xu, Chongfeng,et al. Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation[J]. GENE,2018,646:47-55.
APA	Bao, Qi,Li, Chong,Xu, Chongfeng,Zhang, Ruiying,Zhao, Kai,&Duan, Ziyuan.(2018).Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation.GENE,646,47-55.
MLA	Bao, Qi,et al."Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation".GENE 646(2018):47-55.