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| Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation | |
| Bao, Qi1,2,3,5; Li, Chong4; Xu, Chongfeng3; Zhang, Ruiying3; Zhao, Kai1,2; Duan, Ziyuan3 | |
| 2018-03-10 | |
| Source Publication | GENE
 |
| Volume | 646Pages:47-55 |
| Subtype | Article |
| Abstract | Porcine butyrophilin-like 5 (Btnl5) is a novel member of the butyrophilin family, which consists of immune regulators. The expression pattern and the function of this gene remain unclear. In this study, Btnl5 is identified as a negative regulator of the NF-kappa B pathway. Our study indicates that Btnl5 is mainly expressed in intestinal epithelial cells (IECs) and expressed in membrane systems. Btnl5 inhibits MyD88-mediated activation of the NF-kappa B pathway. Btnl5 interacts with TNF receptor-associated factor 2 (TRAF2) and transcription factor p65. Besides, Btnl5 inhibits p65-mediated activation of the NF-kappa B pathway and inhibits nuclear translocation of p65. These results suggest that Btnl5 may inhibit NF-kappa B pathway through binding and interfere nuclear translocation of p65. |
| Keyword | Btnl5 Iecs Nf-kappa b Immune Regulation Interacting Proteins |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| DOI | 10.1016/j.gene.2017.11.070 |
| WOS Keyword | ULCERATIVE-COLITIS ; GENE FAMILY ; INFLAMMATION ; ALPHA ; BUTYROPHILINS ; HOMEOSTASIS ; ACTIVATION ; CELLS |
| Indexed By | SCI |
| Language | 英语 |
| Funding Organization | National Program on Key Basic Research Project (973 Program)(2013CB835200) |
| WOS Research Area | Genetics & Heredity |
| WOS Subject | Genetics & Heredity |
| WOS ID | WOS:000425080000007 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://210.75.249.4/handle/363003/13334 |
| Collection | 中国科学院西北高原生物研究所 |
| Affiliation | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Qinghai, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Lab Plateau Fish Evolutionary & Funct Genom, Xining 810001, Qinghai, Peoples R China 3.Chinese Acad Sci, Genet Resource Ctr, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Biophys, Core Facil Prot Res, Beijing 100101, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Bao, Qi,Li, Chong,Xu, Chongfeng,et al. Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation[J]. GENE,2018,646:47-55. |
| APA | Bao, Qi,Li, Chong,Xu, Chongfeng,Zhang, Ruiying,Zhao, Kai,&Duan, Ziyuan.(2018).Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation.GENE,646,47-55. |
| MLA | Bao, Qi,et al."Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation".GENE 646(2018):47-55. |
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