A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens

doi:10.1080/14786419.2017.1338278

NWIPB OpenIR

	A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens
	Zhang, Shan-Shan 1; Liao, Zhi-Xin 1; Huang, Ri-Zhen 1; Gong, Cheng-Cheng 1; Ji, Lan-Ju 2; Sun, Hong-Fa 2
	2018
发表期刊	NATURAL PRODUCT RESEARCH
卷号	32 期号:6 页码:668-675
文章类型	Article
摘要	Chemical investigation of the ethanolic extracts of the dried leaves of Bergenia purpurascens led to the isolation and identification of a new aromatic glycoside, 1-O-ss-D-glucopyranosyl-2-methoxy-3-hydroxylphenylethene( 1), along with other 19 known compounds (2-20). The structure of compound 1 was determined by a detailed analysis using various analytical techniques, including 1D and 2D NMR. In vitro anti- proliferative activities of compound 1 on five human cancer cell lines were evaluated. The results showed that compound 1 possessed the most potent effects with the IC50 values of 14.36 +/- 1.04 mu M against T24 cells. The further bioactivity analysis showed that compound 1 induced apoptosis of T24 cells, and altered anti- and pro-apoptotic proteins, leading to mitochondrial dysfunction and activation of caspase-3 for causing cell apoptosis. The present investigation illustrated compound 1 might be used as a potential antitumour chemotherapy candidate.
关键词	Bergenia Purpurascens Aromatic Glycoside Cancer Cell Lines Anti-proliferative Activities Docking Model
WOS标题词	Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
DOI	10.1080/14786419.2017.1338278
关键词[WOS]	CHEMICAL-COMPONENTS ; LIGULATA ; INHIBITORS
收录类别	SCI
语种	英语
项目资助者	State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University)(CMEMR 2016-B06)
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS类目	Chemistry, Applied ; Chemistry, Medicinal
WOS记录号	WOS:000426942800007
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/13343
专题	中国科学院西北高原生物研究所
作者单位	1.Southeast Univ, Sch Chem & Chem Engn, Nanjing, Jiangsu, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Shan-Shan,Liao, Zhi-Xin,Huang, Ri-Zhen,et al. A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens[J]. NATURAL PRODUCT RESEARCH,2018,32(6):668-675.
APA	Zhang, Shan-Shan,Liao, Zhi-Xin,Huang, Ri-Zhen,Gong, Cheng-Cheng,Ji, Lan-Ju,&Sun, Hong-Fa.(2018).A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens.NATURAL PRODUCT RESEARCH,32(6),668-675.
MLA	Zhang, Shan-Shan,et al."A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens".NATURAL PRODUCT RESEARCH 32.6(2018):668-675.