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Simultaneous Determination of Oleanolic Acid and Ursolic Acid by in Vivo Microdialysis via UHPLC-MS/MS Using Magnetic Dispersive Solid Phase Extraction Coupling with Microwave-Assisted Derivatization and Its Application to a Pharmacokinetic Study of Arctiumlappa L. Root Extract in Rats
Zheng, Zhenjia1; Zhao, Xian-En4; Zhu, Shuyun4; Dang, Jun2,3; Qiao, Xuguang1; Qiu, Zhichang1; Tao, Yanduo2,3
2018-04-18
发表期刊JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷号66期号:15页码:3975-3982
文章类型Article
摘要Simultaneous detection of oleanolic acid and ursolic acid in rat blood by in vivo microdialysis can provide important pharmacokinetics information. Microwave-assisted derivatization coupled with magnetic dispersive solid phase extraction was established for the determination of oleanolic acid and ursolic acid by liquid chromatography tandem mass spectrometry. 2'-Carbonyl-piperazine rhodamine B was first designed and synthesized as the derivatization reagent, which was easily adsorbed onto the surface of Fe3O4/graphene oxide. Simultaneous derivatization and extraction of oleanolic acid and ursolic acid were performed on Fe3O4/graphene oxide. The permanent positive charge of the derivatization reagent significantly improved the ionization efficiencies. The limits of detection were 0.025 and 0.020 ng/mL for oleanolic acid and ursolic acid, respectively. The validated method was shown to be promising for sensitive, accurate, and simultaneous determination of oleanolic acid and ursolic acid. It was used for their pharmacokinetics study in rat blood after oral administration of Arctiumlappa L. root extract.
关键词In Vivo Microdialysis Triterpenic Acid Microwave-assisted Derivatization Magnetic Graphene Oxide Pharmacokinetics ArctiumL.ppa L. Root
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1021/acs.jafc.7b06015
关键词[WOS]LIQUID-LIQUID MICROEXTRACTION ; CHROMATOGRAPHY-MASS SPECTROMETRY ; MOLECULARLY IMPRINTED POLYMERS ; TRITERPENIC ACIDS ; FLUORESCENCE DETECTION ; GRAPHENE OXIDE ; SITU DERIVATIZATION ; SAMPLES ; PRETREATMENT ; MS
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(21775088 ; Special Fund for Agro-scientific Research in the Public Interest(201503142) ; Innovation Platform for the Development and Construction of Special Project of Key Laboratory of Tibetan Medicine Research of Qinghai Province(2017-ZJ-Y11) ; Open Projects Program of the Key Laboratory of Tibetan Medicine Research of Chinese Academy of Sciences ; 21405094 ; 81303179)
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
WOS类目Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS记录号WOS:000430642200026
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/13354
专题中国科学院西北高原生物研究所
作者单位1.Shandong Agr Univ, Coll Food Sci & Engn, 61 Daizong St, Tai An 271018, Shandong, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810001, Qinghai, Peoples R China
3.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810001, Qinghai, Peoples R China
4.Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Zhenjia,Zhao, Xian-En,Zhu, Shuyun,et al. Simultaneous Determination of Oleanolic Acid and Ursolic Acid by in Vivo Microdialysis via UHPLC-MS/MS Using Magnetic Dispersive Solid Phase Extraction Coupling with Microwave-Assisted Derivatization and Its Application to a Pharmacokinetic Study of Arctiumlappa L. Root Extract in Rats[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(15):3975-3982.
APA Zheng, Zhenjia.,Zhao, Xian-En.,Zhu, Shuyun.,Dang, Jun.,Qiao, Xuguang.,...&Tao, Yanduo.(2018).Simultaneous Determination of Oleanolic Acid and Ursolic Acid by in Vivo Microdialysis via UHPLC-MS/MS Using Magnetic Dispersive Solid Phase Extraction Coupling with Microwave-Assisted Derivatization and Its Application to a Pharmacokinetic Study of Arctiumlappa L. Root Extract in Rats.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(15),3975-3982.
MLA Zheng, Zhenjia,et al."Simultaneous Determination of Oleanolic Acid and Ursolic Acid by in Vivo Microdialysis via UHPLC-MS/MS Using Magnetic Dispersive Solid Phase Extraction Coupling with Microwave-Assisted Derivatization and Its Application to a Pharmacokinetic Study of Arctiumlappa L. Root Extract in Rats".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.15(2018):3975-3982.
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