Oxygen-Generating MnO2 Nanodots-Anchored Versatile Nanoplatform for Combined Chemo-Photodynamic Therapy in Hypoxic Cancer

doi:10.1002/adfm.201706375

NWIPB OpenIR

	Oxygen-Generating MnO2 Nanodots-Anchored Versatile Nanoplatform for Combined Chemo-Photodynamic Therapy in Hypoxic Cancer
	Zhang, Wentao 1; Li, Sihang 1; Liu, Xinnan 1; Yang, Chengyuan 1; Hu, Na 2; Dou, Leina 1; Zhao, Bingxin 1; Zhang, Qinying 1; Suo, Yourui 2; Wang, Jianlong 1
	2018-03-28
发表期刊	ADVANCED FUNCTIONAL MATERIALS
卷号	28 期号:13
文章类型	Article
摘要	Local hypoxia in tumors results in undesirable impediments for the efficiencies of oxygen-dependent chemical and photodynamic therapy (PDT). Herein, a versatile oxygen-generating and pH-responsive nanoplatform is developed by loading MnO2 nanodots onto the nanosystem that encapsulates g-C3N4 and doxorubicin hydrochloride to overcome the hypoxia-caused resistance in cancer therapy. The loaded MnO2 nanodots can react with endogenous acidic H2O2 to elevate the dissolved oxygen concentration, leading to considerably enhanced cancer therapy efficacy. As such, the as-prepared nanoplatform with excellent dispersibility and satisfactory biocompatibility can sustainably increase the oxygen concentration and rapidly release the encapsulated drugs in acid H2O2 environment. In vitro cytotoxicity experiments show a higher therapy effect by the designed nanoplatform, when compared to therapy without MnO2 nanodots under hypoxia condition, or chemical and photodynamic therapy alone with the presence of MnO2 nanodots. In vivo experiments also demonstrate that 4T1 tumors can be very efficiently eliminated by the designed nanoplatform under light irradiation. These results highlight that the MnO2 nanodots-based nanoplatform is promising for elevating the oxygen level in tumor microenvironments to overcome hypoxia limitations for high-performance cancer therapy.
关键词	Chemotherapy Hypoxia Mno2 Nanodots Photodynamic Therapy Resistance
WOS标题词	Science & Technology ; Physical Sciences ; Technology
DOI	10.1002/adfm.201706375
关键词[WOS]	SOLID TUMOR MICROENVIRONMENT ; METAL-ORGANIC FRAMEWORKS ; INDUCED RESISTANCE ; ALBUMIN-MNO2 NANOPARTICLES ; COMBINATION THERAPY ; DRUG-DELIVERY ; NANOMATERIALS ; NANOCARRIERS ; DOXORUBICIN ; TARGET
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(21675127) ; Fundamental Research Funds for the Northwest A&F University of China(2014YB093 ; Development Project of Qinghai Key Laboratory(2017-ZJ-Y10) ; 2452015257)
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000428792200020
引用统计	被引频次：206[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/13365
专题	中国科学院西北高原生物研究所
作者单位	1.Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Plateau Biol, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Xining 810008, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Wentao,Li, Sihang,Liu, Xinnan,et al. Oxygen-Generating MnO2 Nanodots-Anchored Versatile Nanoplatform for Combined Chemo-Photodynamic Therapy in Hypoxic Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(13).
APA	Zhang, Wentao.,Li, Sihang.,Liu, Xinnan.,Yang, Chengyuan.,Hu, Na.,...&Wang, Jianlong.(2018).Oxygen-Generating MnO2 Nanodots-Anchored Versatile Nanoplatform for Combined Chemo-Photodynamic Therapy in Hypoxic Cancer.ADVANCED FUNCTIONAL MATERIALS,28(13).
MLA	Zhang, Wentao,et al."Oxygen-Generating MnO2 Nanodots-Anchored Versatile Nanoplatform for Combined Chemo-Photodynamic Therapy in Hypoxic Cancer".ADVANCED FUNCTIONAL MATERIALS 28.13(2018).