Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization

doi:10.3389/fmicb.2018.01745

NWIPB OpenIR

	Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization
	Li, Huan 1; Li, Tongtong 2; Li, Xiangzhen 3; Wang, Guanhong 4; Lin, Qiang 5; Qu, Jiapeng6,7
	2018-07-31
发表期刊	FRONTIERS IN MICROBIOLOGY
ISSN	1664-302X
卷号	9
文章类型	Article
摘要	Urbanization is associated with shifts in human lifestyles, thus possibly influencing the diversity, interaction and assembly of gut microbiota. However, the question regarding how human gut microbiota adapts to varying lifestyles remains elusive. To understand the relationship between gut microbiota and urbanization, we compared the diversity, interaction and assembly of gut microbial communities of herdsmen from three regions with different levels of urbanization, namely traditional herdsmen (TH), semi-urban herdsmen (SUH) and urban herdsmen (UH). The relative abundance of Prevotella decreased with the degree of urbanization (from TH to UH), whereas that of Bacteroides, Faecalibacterium, and Blautia showed an opposite trend. Although the alpha diversity measures (observed OTUs and phylogenetic diversity) of gut microbiota were unaffected by urbanization, the beta diversity (Jaccard or Bray-Curtis distances) was significantly influenced by urbanization. Metagenome prediction revealed that the gene functions associated with metabolism (i.e., carbohydrate and lipid metabolism) had significant differences between TH and UH. Network analysis showed that the modularity increased with the degree of urbanization, indicating a high extent of niche differentiation in UH. Meanwhile the trend of network density was opposite, indicating a more complex network in TH. Notably, the relative importance of environmental filtering that governed the community assembly increased with the degree of urbanization, which indicated that deterministic factors (e.g , low-fiber diet) play more important roles than stochastic factors (e.g., stochastic dispersal) in shaping the gut microbiota. A quantification of ecological processes showed a stronger signal of variable selection in UH than TH, implying that different selective pressures cause divergent gut community compositions due to urban lifestyles. Our results suggest that beta diversity, network interactions and ecological processes of gut microbiota may reflect the degree of urbanization, and highlight the adaptation of human gut microbiota to lifestyle changes.
关键词	Gut Microbiota Urbanization Beta Diversity Network Interaction Environmental Filtering Lifestyle
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.3389/fmicb.2018.01745
关键词[WOS]	ECOLOGICAL PROCESSES ; ASSEMBLY PROCESSES ; NEUTRAL THEORY ; DIVERSITY ; COMMUNITIES ; PATTERNS ; SUCCESSION ; GRADIENTS ; SEQUENCES ; ECOSYSTEM
收录类别	SCI
语种	英语
项目资助者	Fundamental Research Funds for the Central Universities(lzujbky-2018-68) ; National Natural Science foundation of China(31770459 ; Youth Innovation Promotion Association CAS ; CAS "Light of West China" Program ; Construction Fund for Qinghai Key Laboratories(2017-ZJ-Y20) ; Zhejiang Provincial Natural Science Foundation of China(LY18E090010) ; 31670503)
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:000440311400001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：24[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/13775
专题	中国科学院西北高原生物研究所
通讯作者	Li, Xiangzhen; Qu, Jiapeng
作者单位	1.Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China 2.Zhejiang Univ Technol, Dept Appl Biol, Coll Biotechnol & Bioengn, Hangzhou, Zhejiang, Peoples R China 3.Chinese Acad Sci, Key Lab Environm & Appl Microbiol, Environm Microbiol Key Lab Sichuan Prov, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China 4.Harvard Univ, Rowland Inst Harvard, Cambridge, MA 02138 USA 5.Czech Acad Sci, Inst Soil Biol, Ceske Budejovice, Czech Republic 6.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Qinghai, Peoples R China 7.Qinghai Prov Key Lab Restorat Ecol Cold Reg, Xining, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Li, Huan,Li, Tongtong,Li, Xiangzhen,et al. Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization[J]. FRONTIERS IN MICROBIOLOGY,2018,9.
APA	Li, Huan,Li, Tongtong,Li, Xiangzhen,Wang, Guanhong,Lin, Qiang,&Qu, Jiapeng.(2018).Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization.FRONTIERS IN MICROBIOLOGY,9.
MLA	Li, Huan,et al."Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization".FRONTIERS IN MICROBIOLOGY 9(2018).