Knowledge Management System of Northwest Institute of Plateau Biology, CAS
The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells | |
Sun, Pengcheng1; Wang, Song1; Wang, Jian1; Sun, Jing2; Peng, Min2; Shi, Ping1,2 | |
2018-06-01 | |
发表期刊 | METALLOMICS |
ISSN | 1756-5901 |
卷号 | 10期号:6页码:838-845 |
文章类型 | Article |
摘要 | Chemerin exhibits a tumor-inhibitory role in hepatocellular carcinoma. However, the effect of chemerin on essential metal elements in hepatic cells remains unclear. In our study, the contents of six important metal ions, including potassium, calcium, sodium, magnesium, iron and zinc, were detected in human hepatoma SMMC7721 and immortal hepatic QSG7701 cells by ICP-AES. The data showed that chemerin only decreases the content of intracellular iron in SMMC7721 cells. The reduction was due to the blockage of iron entry through the decrease in the mRNA levels of divalent metal transporter 1, iron regulatory proteins and transferrin receptors. Furthermore, the reduction of the cellular iron content induced alterations of p53-p27-p21 signaling to arrest the cell cycle at S phase in SMMC7721 cells treated by chemerin. Conversely, iron addition led to recovery from the inhibitory effect of chemerin on SMMC7721 cells. The results suggest that chemerin plays an important role in inhibiting the cell proliferation of hepatocellular carcinomas by interfering with cellular iron homeostasis in this type of tumors. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1039/c8mt00099a |
关键词[WOS] | TRANSFERRIN-BOUND IRON ; DENDRITIC CELLS ; PROTEIN-LEVELS ; RECEPTOR ; METABOLISM ; CANCER ; LIVER ; HEPATOCYTES ; EXPRESSION ; COMPLEX |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | National Natural Science Foundation of China(31671309) ; Development Project of Qinghai Key Laboratory(2017-ZJ-Y10) |
WOS研究方向 | Biochemistry & Molecular Biology |
WOS类目 | Biochemistry & Molecular Biology |
WOS记录号 | WOS:000436031100006 |
出版者 | ROYAL SOC CHEMISTRY |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/13787 |
专题 | 中国科学院西北高原生物研究所 |
通讯作者 | Sun, Jing; Shi, Ping |
作者单位 | 1.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Xiguan Ave 59, Xining 810001, Qinghai, Peoples R China |
推荐引用方式 GB/T 7714 | Sun, Pengcheng,Wang, Song,Wang, Jian,et al. The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells[J]. METALLOMICS,2018,10(6):838-845. |
APA | Sun, Pengcheng,Wang, Song,Wang, Jian,Sun, Jing,Peng, Min,&Shi, Ping.(2018).The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells.METALLOMICS,10(6),838-845. |
MLA | Sun, Pengcheng,et al."The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells".METALLOMICS 10.6(2018):838-845. |
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