The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells

doi:10.1039/c8mt00099a

NWIPB OpenIR

	The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells
	Sun, Pengcheng 1; Wang, Song 1; Wang, Jian 1; Sun, Jing 2; Peng, Min2 ; Shi, Ping 1,2
	2018-06-01
发表期刊	METALLOMICS
ISSN	1756-5901
卷号	10 期号:6 页码:838-845
文章类型	Article
摘要	Chemerin exhibits a tumor-inhibitory role in hepatocellular carcinoma. However, the effect of chemerin on essential metal elements in hepatic cells remains unclear. In our study, the contents of six important metal ions, including potassium, calcium, sodium, magnesium, iron and zinc, were detected in human hepatoma SMMC7721 and immortal hepatic QSG7701 cells by ICP-AES. The data showed that chemerin only decreases the content of intracellular iron in SMMC7721 cells. The reduction was due to the blockage of iron entry through the decrease in the mRNA levels of divalent metal transporter 1, iron regulatory proteins and transferrin receptors. Furthermore, the reduction of the cellular iron content induced alterations of p53-p27-p21 signaling to arrest the cell cycle at S phase in SMMC7721 cells treated by chemerin. Conversely, iron addition led to recovery from the inhibitory effect of chemerin on SMMC7721 cells. The results suggest that chemerin plays an important role in inhibiting the cell proliferation of hepatocellular carcinomas by interfering with cellular iron homeostasis in this type of tumors.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1039/c8mt00099a
关键词[WOS]	TRANSFERRIN-BOUND IRON ; DENDRITIC CELLS ; PROTEIN-LEVELS ; RECEPTOR ; METABOLISM ; CANCER ; LIVER ; HEPATOCYTES ; EXPRESSION ; COMPLEX
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(31671309) ; Development Project of Qinghai Key Laboratory(2017-ZJ-Y10)
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000436031100006
出版者	ROYAL SOC CHEMISTRY
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/13787
专题	中国科学院西北高原生物研究所
通讯作者	Sun, Jing; Shi, Ping
作者单位	1.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Xiguan Ave 59, Xining 810001, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Sun, Pengcheng,Wang, Song,Wang, Jian,et al. The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells[J]. METALLOMICS,2018,10(6):838-845.
APA	Sun, Pengcheng,Wang, Song,Wang, Jian,Sun, Jing,Peng, Min,&Shi, Ping.(2018).The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells.METALLOMICS,10(6),838-845.
MLA	Sun, Pengcheng,et al."The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells".METALLOMICS 10.6(2018):838-845.