Polyphenol Stilbenes from Fenugreek (Trigonella foenum-graecum L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3-L1 Adipocytes

doi:10.1155/2018/7634362

NWIPB OpenIR

	Polyphenol Stilbenes from Fenugreek (Trigonella foenum-graecum L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3-L1 Adipocytes
	Li, Gang 1; Luan, Guangxiang 2,4; He, Yanfeng 3; Tie, Fangfang 2,4; Wang, Zhenhua 1; Suo, Yourui2 ; Ma, Chengjun 1; Wang, Honglun2
	2018
发表期刊	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
ISSN	1942-0900
文章类型	Article
摘要	Fenugreek (Trigonella foenum-graecutn L.) is a well-known annual plant that is widely distributed worldwide and has possessed obvious hypoglycemic and hypercholesterolemia characteristics. In our previous study, three polyphenol stilbenes were separated from fenugreek seeds. Here, we investigated the effect of polyphenol stilbenes on adipogenesis and insulin resistance in 3T3-L1 adipocytes. Oil Red O staining and triglyceride assays showed that polyphenol stilbenes differently reduced lipid accumulation by suppressing the expression of adipocyte-specific proteins. In addition, polyphenol stilbenes improved the uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) by promoting the phosphorylation of protein kinase B (AKT) and AMP-activated protein kinase (AMPK). In present studies, it was found that polyphenol stilbenes had the ability to scavenge reactive oxygen species (ROS). Results from adenosine triphosphate (ATP) production and mitochondria' membrane potentials suggested that mitochondria play a critical role in insulin resistance and related signaling activation, such as AKT and AMPK. Rhaponticin, one of the stilbenes from fenugreek, had the strongest activity among the three compounds in vitro. Future studies will focus on mitochondrial biogenesis and function.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1155/2018/7634362
关键词[WOS]	INDUCED DIABETIC-RATS ; BLOOD-GLUCOSE ; RESISTANCE ; EXTRACT ; CHROMATOGRAPHY ; PTEROSTILBENE ; RESVERATROL ; ANTIOXIDANT ; FLAVONOIDS ; DISEASE
收录类别	SCI
语种	英语
项目资助者	National Science Foundation of China(31470426 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12040320) ; Shandong Provincial Science Foundation(ZR2017MH024) ; Shuangbai Project of Yantai ; Qinghai Provincial Science Foundation(2016-ZJ-929Q ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; 31300292) ; 2015-SF-121)
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000435829400001
出版者	HINDAWI LTD
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/13789
专题	中国科学院西北高原生物研究所
通讯作者	Wang, Honglun
作者单位	1.Yantai Univ, Coll Life Sci, Ctr Mitochondria & Hlth Aging, Yantai 264005, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China 3.Qinghai Nationalities Univ, Coll Pharm, Xining 810008, Qinghai, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Gang,Luan, Guangxiang,He, Yanfeng,et al. Polyphenol Stilbenes from Fenugreek (Trigonella foenum-graecum L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3-L1 Adipocytes[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2018.
APA	Li, Gang.,Luan, Guangxiang.,He, Yanfeng.,Tie, Fangfang.,Wang, Zhenhua.,...&Wang, Honglun.(2018).Polyphenol Stilbenes from Fenugreek (Trigonella foenum-graecum L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3-L1 Adipocytes.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY.
MLA	Li, Gang,et al."Polyphenol Stilbenes from Fenugreek (Trigonella foenum-graecum L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3-L1 Adipocytes".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018).