ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample

doi:10.1016/j.snb.2018.04.150

NWIPB OpenIR

	ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample
	Huang, Lunjie 1; Chen, Kai 1; Zhang, Wentao 1; Zhu, Wenxin 1; Liu, Xinnan 1; Wang, Jing 1; Wang, Rong 1; Hu, Na 2; Suo, Yourui2 ; Wang, Jianlong 1
	2018-09-15
发表期刊	SENSORS AND ACTUATORS B-CHEMICAL
ISSN	0925-4005
卷号	269 页码:87-95
文章类型	Article
摘要	Nanozyme technique with efficient modulating strategies is a promising tool for biocatalytic and biosensing applications, yet insights into target-responsive controllability of oxidase nanozymes remain largely unknown. In this contribution, we report a state-of-art oxidase-like and ssDNA-tunable nanozyme for biomolecular recognition. In detail, the spinel-type manganese cation substituted cobalt oxide (MnCo2O4) submicrospheres can imitate oxidase for efficiently catalytic oxidation of colorimetric substrate, superior to current metal oxide-based oxidase nanozymes. More importantly, the nanozyme activity of spinel MnCo2O4 can be reversibly inhibited by the attachment/detachment of aptamer strands on MnCo2O4 surface via the aptamer-target binding event, enabling a new colorimetric access for detecting biomolecules. Taking highly toxic ochratoxin A (OTA) as model molecule, we can selectively determine OTA in maize samples with a limit of detection (3 delta/S) of 0.08 ng/mL. The unique nanozyme property of spinel MnCo2O4, together with the principle of our approach, reveals the potential of ssDNA-tailorable oxidase nanozymes in biocatalytic and biosensing fields. (C) 2018 Elsevier B.V. All rights reserved.
关键词	Activity Modulation Aptamer Biosensor Food Analysis Nanozyme Oxidase
WOS标题词	Science & Technology ; Physical Sciences ; Technology
DOI	10.1016/j.snb.2018.04.150
关键词[WOS]	PEROXIDASE-LIKE ACTIVITY ; COLORIMETRIC DETECTION ; NANOZYME ACTIVITY ; VISIBLE-LIGHT ; QUANTUM DOTS ; COCOA BEANS ; OCHRATOXIN ; NANOPARTICLES ; DNA ; APTASENSOR
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(21675127) ; Fundamental Research Funds for the Central Universities(2014YB093 ; Development Project of Qinghai Key Laboratory(2017-ZJ-Y10) ; 2452015257)
WOS研究方向	Chemistry ; Electrochemistry ; Instruments & Instrumentation
WOS类目	Chemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS记录号	WOS:000433211100012
出版者	ELSEVIER SCIENCE SA
引用统计	被引频次：65[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/13793
专题	中国科学院西北高原生物研究所
通讯作者	Wang, Jianlong
作者单位	1.Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Xining 810008, Qinghai, Peoples R China
推荐引用方式 GB/T 7714	Huang, Lunjie,Chen, Kai,Zhang, Wentao,et al. ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018,269:87-95.
APA	Huang, Lunjie.,Chen, Kai.,Zhang, Wentao.,Zhu, Wenxin.,Liu, Xinnan.,...&Wang, Jianlong.(2018).ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample.SENSORS AND ACTUATORS B-CHEMICAL,269,87-95.
MLA	Huang, Lunjie,et al."ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample".SENSORS AND ACTUATORS B-CHEMICAL 269(2018):87-95.