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An antioxidant alpha-glucan from Cladina rangiferina (L) Nyl. and its protective effect on alveolar epithelial cells from Pb2+-induced oxidative damage
Huang, Xiaojuan1,2,3; Ma, Jianbin4; Wei, Lixin1,2; Song, Jiayin5; Li, Cen1,2; Yang, Hongxia1,2; Du, Yuzhi1,2; Gao, Tingting2; Bi, Hongtao1
2018-06-01
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume112Pages:101-109
SubtypeArticle
AbstractAir pollution is a serious global health problem nowadays. So, it is an emergency to pay sufficient attention to treat and prevent the diseases caused by air pollution, especially respiratory disease and lung damage. Cladina rangiferina (L) Nyl. is an edible lichen that has been used in medicinal diets to treat respiratory and other diseases for over 500 years. In this study, a water-soluble polysaccharide, CRWP-P, was obtained from C rangiferina by hot-water extraction, freeze-thawing separation, and Fehling reagent purification. Structural analysis showed that CRWP-P is a linear alpha-(1 -> 3),(1 -> 4)-D-glucan without branches. Its Mw was determined to be 1.05 x 10(5) Da. Its (1,3)-alpha-D-glucopyranosyl: (1,4)-alpha-D-glucopyranosyl ratio is approximately 1:2. Antioxidant activity assay showed that C. rangiferina polysaccharides, especially CRWP-P. had appreciable DPPH radical-scavenging activity and reducing power. Notably, they could effectively decrease cell breakdown and ROS generation, inhibit lipid peroxidation, increase key antioxidase activity, and promote glutathione redox cycling in Pb2+-oxidative injured A549 alveolar epithelium cells. Overall, the results of this study indicated that C rangiferina polysaccharides, especially CRWP-P, have the potential to be natural antioxidants for the treatment of lung oxidative damage induced by lead of air pollutants. (C) 2018 Elsevier B.V. All rights reserved.
KeywordCladina Rangiferina (l) Nyl. Alpha-glucan Antioxidant Activity Alveolar Epithelium Cell pb2+-oxidative Toxicity Protection
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1016/j.ijbiomac.2018.01.154
WOS KeywordIN-VITRO ANTIOXIDANT ; STRUCTURAL-CHARACTERIZATION ; LIPID-PEROXIDATION ; PARTICULATE MATTER ; CETRARIA-ISLANDICA ; POLYSACCHARIDES ; LICHENS ; DERIVATIVES ; ASSAY ; LEAD
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31400310 ; Applying Basic Research Program of Qinghai Province(2015-ZJ-727) ; Key Laboratory Special Development Program of Qinghai Province(2017-ZJ-Y08) ; Natural Science Foundation of Tianjin City(15JCQJC07500) ; 51408405)
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS IDWOS:000430522400012
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/13833
Collection中国科学院西北高原生物研究所
Corresponding AuthorGao, Tingting; Bi, Hongtao
Affiliation1.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining, Qinghai, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, 23 Xining Rd, Xining 810008, Qinghai, Peoples R China
3.Sichuan Univ, Natl Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China
4.Qinghai Normal Univ, Sch Life & Geog Sci, Xining, Qinghai, Peoples R China
5.Tianjin Univ, Tianjin Key Lab Architectural Phys & Environm Tec, Tianjin, Peoples R China
Recommended Citation
GB/T 7714
Huang, Xiaojuan,Ma, Jianbin,Wei, Lixin,et al. An antioxidant alpha-glucan from Cladina rangiferina (L) Nyl. and its protective effect on alveolar epithelial cells from Pb2+-induced oxidative damage[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,112:101-109.
APA Huang, Xiaojuan.,Ma, Jianbin.,Wei, Lixin.,Song, Jiayin.,Li, Cen.,...&Bi, Hongtao.(2018).An antioxidant alpha-glucan from Cladina rangiferina (L) Nyl. and its protective effect on alveolar epithelial cells from Pb2+-induced oxidative damage.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,112,101-109.
MLA Huang, Xiaojuan,et al."An antioxidant alpha-glucan from Cladina rangiferina (L) Nyl. and its protective effect on alveolar epithelial cells from Pb2+-induced oxidative damage".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 112(2018):101-109.
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