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An antioxidant alpha-glucan from Cladina rangiferina (L) Nyl. and its protective effect on alveolar epithelial cells from Pb2+-induced oxidative damage
Huang, Xiaojuan1,2,3; Ma, Jianbin4; Wei, Lixin1,2; Song, Jiayin5; Li, Cen1,2; Yang, Hongxia1,2; Du, Yuzhi1,2; Gao, Tingting2; Bi, Hongtao1
2018-06-01
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
卷号112页码:101-109
文章类型Article
摘要Air pollution is a serious global health problem nowadays. So, it is an emergency to pay sufficient attention to treat and prevent the diseases caused by air pollution, especially respiratory disease and lung damage. Cladina rangiferina (L) Nyl. is an edible lichen that has been used in medicinal diets to treat respiratory and other diseases for over 500 years. In this study, a water-soluble polysaccharide, CRWP-P, was obtained from C rangiferina by hot-water extraction, freeze-thawing separation, and Fehling reagent purification. Structural analysis showed that CRWP-P is a linear alpha-(1 -> 3),(1 -> 4)-D-glucan without branches. Its Mw was determined to be 1.05 x 10(5) Da. Its (1,3)-alpha-D-glucopyranosyl: (1,4)-alpha-D-glucopyranosyl ratio is approximately 1:2. Antioxidant activity assay showed that C. rangiferina polysaccharides, especially CRWP-P. had appreciable DPPH radical-scavenging activity and reducing power. Notably, they could effectively decrease cell breakdown and ROS generation, inhibit lipid peroxidation, increase key antioxidase activity, and promote glutathione redox cycling in Pb2+-oxidative injured A549 alveolar epithelium cells. Overall, the results of this study indicated that C rangiferina polysaccharides, especially CRWP-P, have the potential to be natural antioxidants for the treatment of lung oxidative damage induced by lead of air pollutants. (C) 2018 Elsevier B.V. All rights reserved.
关键词Cladina Rangiferina (l) Nyl. Alpha-glucan Antioxidant Activity Alveolar Epithelium Cell pb2+-oxidative Toxicity Protection
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1016/j.ijbiomac.2018.01.154
关键词[WOS]IN-VITRO ANTIOXIDANT ; STRUCTURAL-CHARACTERIZATION ; LIPID-PEROXIDATION ; PARTICULATE MATTER ; CETRARIA-ISLANDICA ; POLYSACCHARIDES ; LICHENS ; DERIVATIVES ; ASSAY ; LEAD
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(31400310 ; Applying Basic Research Program of Qinghai Province(2015-ZJ-727) ; Key Laboratory Special Development Program of Qinghai Province(2017-ZJ-Y08) ; Natural Science Foundation of Tianjin City(15JCQJC07500) ; 51408405)
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号WOS:000430522400012
出版者ELSEVIER SCIENCE BV
引用统计
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/13833
专题中国科学院西北高原生物研究所
通讯作者Gao, Tingting; Bi, Hongtao
作者单位1.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining, Qinghai, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, 23 Xining Rd, Xining 810008, Qinghai, Peoples R China
3.Sichuan Univ, Natl Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China
4.Qinghai Normal Univ, Sch Life & Geog Sci, Xining, Qinghai, Peoples R China
5.Tianjin Univ, Tianjin Key Lab Architectural Phys & Environm Tec, Tianjin, Peoples R China
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Huang, Xiaojuan,Ma, Jianbin,Wei, Lixin,et al. An antioxidant alpha-glucan from Cladina rangiferina (L) Nyl. and its protective effect on alveolar epithelial cells from Pb2+-induced oxidative damage[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,112:101-109.
APA Huang, Xiaojuan.,Ma, Jianbin.,Wei, Lixin.,Song, Jiayin.,Li, Cen.,...&Bi, Hongtao.(2018).An antioxidant alpha-glucan from Cladina rangiferina (L) Nyl. and its protective effect on alveolar epithelial cells from Pb2+-induced oxidative damage.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,112,101-109.
MLA Huang, Xiaojuan,et al."An antioxidant alpha-glucan from Cladina rangiferina (L) Nyl. and its protective effect on alveolar epithelial cells from Pb2+-induced oxidative damage".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 112(2018):101-109.
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