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Analysis of five pharmacologically active compounds from Rhodiola for natural product drug discovery with capillary electrophoresis
Suo, YR; Wang, HL; Li, YL; You, JM; Wang, HQ
2004-11-01
Source PublicationCHROMATOGRAPHIA
Volume60Issue:9-10Pages:589-595
SubtypeArticle
AbstractA rapid capillary electrophoresis method for the separation of five natural pharmacologically active compounds from extracted Rhodiola, namely salidroside, tyrosol, rhodionin, gallic acid and ethyl gallate has been developed. The separation of five natural pharmacologically active compounds was carried out in a fused-silica capillary with 14 mM boric acid, 30 mM SDS and 2.5% acetonitrile, adjusted to pH 10.7 with NaOH. Applied potential was 21 kV. The temperature of the capillary was maintained at 25 degreesC by the instrument thermostating system, with the correlation coefficients of 0.9805-0.9989 for migration time, and relative standards of < 3.52% for peak areas. The established method is rapid and reproducible for the separation of five natural pharmacologically compounds from extracts of Rhodiola with satisfactory results.; A rapid capillary electrophoresis method for the separation of five natural pharmacologically active compounds from extracted Rhodiola, namely salidroside, tyrosol, rhodionin, gallic acid and ethyl gallate has been developed. The separation of five natural pharmacologically active compounds was carried out in a fused-silica capillary with 14 mM boric acid, 30 mM SDS and 2.5% acetonitrile, adjusted to pH 10.7 with NaOH. Applied potential was 21 kV. The temperature of the capillary was maintained at 25 degreesC by the instrument thermostating system, with the correlation coefficients of 0.9805-0.9989 for migration time, and relative standards of < 3.52% for peak areas. The established method is rapid and reproducible for the separation of five natural pharmacologically compounds from extracts of Rhodiola with satisfactory results.
KeywordCapillary Electrophoresis Pharmacologically Active Compounds Rhodiola Crenucata Rhodiola Quadrifida
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
Subject Area生物化学
WOS KeywordHYDROPHILIC-INTERACTION CHROMATOGRAPHY ; MICELLAR ELECTROKINETIC CHROMATOGRAPHY ; SEPARATION ; PEPTIDES ; PHASE ; ELECTROCHROMATOGRAPHY
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS IDWOS:000225079600017
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Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/1386
Collection中国科学院西北高原生物研究所
Affiliation1.Chinese Acad Sci, NW Plateau Inst Biol, Xining 810008, Peoples R China
2.Qufu Normal Univ, Dept Chem, Qufu 273165, Peoples R China
3.Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Suo, YR,Wang, HL,Li, YL,et al. Analysis of five pharmacologically active compounds from Rhodiola for natural product drug discovery with capillary electrophoresis[J]. CHROMATOGRAPHIA,2004,60(9-10):589-595.
APA Suo, YR,Wang, HL,Li, YL,You, JM,&Wang, HQ.(2004).Analysis of five pharmacologically active compounds from Rhodiola for natural product drug discovery with capillary electrophoresis.CHROMATOGRAPHIA,60(9-10),589-595.
MLA Suo, YR,et al."Analysis of five pharmacologically active compounds from Rhodiola for natural product drug discovery with capillary electrophoresis".CHROMATOGRAPHIA 60.9-10(2004):589-595.
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