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Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.
Gao, Tingting1; Ma, Shuai2; Song, Jiayin3; Bi, Hongtao1; Tao, Yanduo1
2011-11-01
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
卷号49期号:4页码:580-586
文章类型Article
摘要Aconitum kusnezoffii Reichb., one of the earliest recorded toxic species of genus Aconitum, has been used as traditional Chinese medicine and medicinal diet over the last 2500 years to treat heart failure congestion, neuralgia, rheumatism and gout, etc. In the present paper, four water-soluble polysaccharide fractions isolated from the tubers of A. kusnezoffii Reichb. were studied the antioxidant and immunological activities for the first time. In vitro antioxidant assays indicated that fraction WKCP-A had noticeable scavenging activities on DPPH radical, hydroxyl radical, superoxide anion, H(2)O(2) and self-oxidation of 1,2,3-phentriol, ferrous ion-chelating ability and reducing power. Moreover, the in vivo immunological assay exhibited that fractions WKCP-A and WKHP could more significantly enhance splenic lymphocyte proliferation and macrophage phagocytosis than other fractions. Therefore, the water-soluble polysaccharides from A. kusnezoffii Reichb., especially WKCP-A, have the potential to be explored as novel natural antioxidants and immunostimulating agents for using in functional foods or medicine. (C) 2011 Elsevier B.V. All rights reserved.; Aconitum kusnezoffii Reichb., one of the earliest recorded toxic species of genus Aconitum, has been used as traditional Chinese medicine and medicinal diet over the last 2500 years to treat heart failure congestion, neuralgia, rheumatism and gout, etc. In the present paper, four water-soluble polysaccharide fractions isolated from the tubers of A. kusnezoffii Reichb. were studied the antioxidant and immunological activities for the first time. In vitro antioxidant assays indicated that fraction WKCP-A had noticeable scavenging activities on DPPH radical, hydroxyl radical, superoxide anion, H2O2 and self-oxidation of 1,2,3-phentriol, ferrous ion-chelating ability and reducing power. Moreover, the in vivo immunological assay exhibited that fractions WKCP-A and WKHP could more significantly enhance splenic lymphocyte proliferation and macrophage phagocytosis than other fractions. Therefore, the water-soluble polysaccharides from A. kusnezoffii Reichb., especially WKCP-A, have the potential to be explored as novel natural antioxidants and immunostimulating agents for using in functional foods or medicine. (C) 2011 Elsevier B.V. All rights reserved.
关键词Aconitum Kusnezoffii Reichb. Polysaccharide Antioxidant Activity Immunological Activity
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]GANODERMA-LUCIDUM ; OXIDATIVE STRESS ; LIPID-PEROXIDATION ; ARROW POISONS ; ASSAY ; AUTOXIDATION ; DERIVATIVES ; SUPEROXIDE ; MECHANISMS ; INHIBITORS
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology
WOS类目Biochemistry & Molecular Biology
WOS记录号WOS:000295502500021
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/1502
专题中国科学院西北高原生物研究所
作者单位1.Chinese Acad Sci, NW Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 130024, Qinghai Provinc, Peoples R China
2.China Med Univ, Dept Oncosurg, Affiliated Hosp 1, Shenyang 110001, Peoples R China
3.Tianjin Univ, Sch Architecture, Tianjin 300072, Peoples R China
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Gao, Tingting,Ma, Shuai,Song, Jiayin,et al. Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2011,49(4):580-586.
APA Gao, Tingting,Ma, Shuai,Song, Jiayin,Bi, Hongtao,&Tao, Yanduo.(2011).Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb..INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,49(4),580-586.
MLA Gao, Tingting,et al."Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 49.4(2011):580-586.
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