Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.

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	Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.
	Gao, Tingting 1; Ma, Shuai 2; Song, Jiayin 3; Bi, Hongtao 1; Tao, Yanduo 1
	2011-11-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	49 期号:4 页码:580-586
文章类型	Article
摘要	Aconitum kusnezoffii Reichb., one of the earliest recorded toxic species of genus Aconitum, has been used as traditional Chinese medicine and medicinal diet over the last 2500 years to treat heart failure congestion, neuralgia, rheumatism and gout, etc. In the present paper, four water-soluble polysaccharide fractions isolated from the tubers of A. kusnezoffii Reichb. were studied the antioxidant and immunological activities for the first time. In vitro antioxidant assays indicated that fraction WKCP-A had noticeable scavenging activities on DPPH radical, hydroxyl radical, superoxide anion, H(2)O(2) and self-oxidation of 1,2,3-phentriol, ferrous ion-chelating ability and reducing power. Moreover, the in vivo immunological assay exhibited that fractions WKCP-A and WKHP could more significantly enhance splenic lymphocyte proliferation and macrophage phagocytosis than other fractions. Therefore, the water-soluble polysaccharides from A. kusnezoffii Reichb., especially WKCP-A, have the potential to be explored as novel natural antioxidants and immunostimulating agents for using in functional foods or medicine. (C) 2011 Elsevier B.V. All rights reserved.; Aconitum kusnezoffii Reichb., one of the earliest recorded toxic species of genus Aconitum, has been used as traditional Chinese medicine and medicinal diet over the last 2500 years to treat heart failure congestion, neuralgia, rheumatism and gout, etc. In the present paper, four water-soluble polysaccharide fractions isolated from the tubers of A. kusnezoffii Reichb. were studied the antioxidant and immunological activities for the first time. In vitro antioxidant assays indicated that fraction WKCP-A had noticeable scavenging activities on DPPH radical, hydroxyl radical, superoxide anion, H2O2 and self-oxidation of 1,2,3-phentriol, ferrous ion-chelating ability and reducing power. Moreover, the in vivo immunological assay exhibited that fractions WKCP-A and WKHP could more significantly enhance splenic lymphocyte proliferation and macrophage phagocytosis than other fractions. Therefore, the water-soluble polysaccharides from A. kusnezoffii Reichb., especially WKCP-A, have the potential to be explored as novel natural antioxidants and immunostimulating agents for using in functional foods or medicine. (C) 2011 Elsevier B.V. All rights reserved.
关键词	Aconitum Kusnezoffii Reichb. Polysaccharide Antioxidant Activity Immunological Activity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	GANODERMA-LUCIDUM ; OXIDATIVE STRESS ; LIPID-PEROXIDATION ; ARROW POISONS ; ASSAY ; AUTOXIDATION ; DERIVATIVES ; SUPEROXIDE ; MECHANISMS ; INHIBITORS
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000295502500021
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/1502
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, NW Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 130024, Qinghai Provinc, Peoples R China 2.China Med Univ, Dept Oncosurg, Affiliated Hosp 1, Shenyang 110001, Peoples R China 3.Tianjin Univ, Sch Architecture, Tianjin 300072, Peoples R China
推荐引用方式 GB/T 7714	Gao, Tingting,Ma, Shuai,Song, Jiayin,et al. Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2011,49(4):580-586.
APA	Gao, Tingting,Ma, Shuai,Song, Jiayin,Bi, Hongtao,&Tao, Yanduo.(2011).Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb..INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,49(4),580-586.
MLA	Gao, Tingting,et al."Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 49.4(2011):580-586.

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