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Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.
Gao, Tingting1; Ma, Shuai2; Song, Jiayin3; Bi, Hongtao1; Tao, Yanduo1
2011-11-01
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume49Issue:4Pages:580-586
SubtypeArticle
AbstractAconitum kusnezoffii Reichb., one of the earliest recorded toxic species of genus Aconitum, has been used as traditional Chinese medicine and medicinal diet over the last 2500 years to treat heart failure congestion, neuralgia, rheumatism and gout, etc. In the present paper, four water-soluble polysaccharide fractions isolated from the tubers of A. kusnezoffii Reichb. were studied the antioxidant and immunological activities for the first time. In vitro antioxidant assays indicated that fraction WKCP-A had noticeable scavenging activities on DPPH radical, hydroxyl radical, superoxide anion, H(2)O(2) and self-oxidation of 1,2,3-phentriol, ferrous ion-chelating ability and reducing power. Moreover, the in vivo immunological assay exhibited that fractions WKCP-A and WKHP could more significantly enhance splenic lymphocyte proliferation and macrophage phagocytosis than other fractions. Therefore, the water-soluble polysaccharides from A. kusnezoffii Reichb., especially WKCP-A, have the potential to be explored as novel natural antioxidants and immunostimulating agents for using in functional foods or medicine. (C) 2011 Elsevier B.V. All rights reserved.; Aconitum kusnezoffii Reichb., one of the earliest recorded toxic species of genus Aconitum, has been used as traditional Chinese medicine and medicinal diet over the last 2500 years to treat heart failure congestion, neuralgia, rheumatism and gout, etc. In the present paper, four water-soluble polysaccharide fractions isolated from the tubers of A. kusnezoffii Reichb. were studied the antioxidant and immunological activities for the first time. In vitro antioxidant assays indicated that fraction WKCP-A had noticeable scavenging activities on DPPH radical, hydroxyl radical, superoxide anion, H2O2 and self-oxidation of 1,2,3-phentriol, ferrous ion-chelating ability and reducing power. Moreover, the in vivo immunological assay exhibited that fractions WKCP-A and WKHP could more significantly enhance splenic lymphocyte proliferation and macrophage phagocytosis than other fractions. Therefore, the water-soluble polysaccharides from A. kusnezoffii Reichb., especially WKCP-A, have the potential to be explored as novel natural antioxidants and immunostimulating agents for using in functional foods or medicine. (C) 2011 Elsevier B.V. All rights reserved.
KeywordAconitum Kusnezoffii Reichb. Polysaccharide Antioxidant Activity Immunological Activity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordGANODERMA-LUCIDUM ; OXIDATIVE STRESS ; LIPID-PEROXIDATION ; ARROW POISONS ; ASSAY ; AUTOXIDATION ; DERIVATIVES ; SUPEROXIDE ; MECHANISMS ; INHIBITORS
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000295502500021
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/1502
Collection中国科学院西北高原生物研究所
Affiliation1.Chinese Acad Sci, NW Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 130024, Qinghai Provinc, Peoples R China
2.China Med Univ, Dept Oncosurg, Affiliated Hosp 1, Shenyang 110001, Peoples R China
3.Tianjin Univ, Sch Architecture, Tianjin 300072, Peoples R China
Recommended Citation
GB/T 7714
Gao, Tingting,Ma, Shuai,Song, Jiayin,et al. Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2011,49(4):580-586.
APA Gao, Tingting,Ma, Shuai,Song, Jiayin,Bi, Hongtao,&Tao, Yanduo.(2011).Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb..INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,49(4),580-586.
MLA Gao, Tingting,et al."Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 49.4(2011):580-586.
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