Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii | |
Pan, Li ; Zhou, Ping ; Zhang, Xiaofeng ; Peng, Shulin ; Ding, Lisheng ; Qiu, Samuel X. | |
2006-06-22 | |
发表期刊 | ORGANIC LETTERS ; Pan Li,Zhou Ping, Zhang Xiaofeng, Peng Shulin, Ding Lisheng,Qiu Samuel X.Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii.ORGANIC LETTERS,2006,8(13):2775-2778 |
摘要 | Two novel rearranged trachylobane diterpenoids, designated as wallichanol A (2) and wallichanol B (3), consisting of an unprecedented pentacyclic skeleton named wallichane with a cyclobutane ring, and a new ent-trachylobane diterpenoid, 3-oxo-ent-trachyloban-17-oic acid (1), were isolated from the roots of Euphorbia wallichii. Their structures were elucidated by comprehensive analysis of 2D-NMR spectroscopic data, with the stereochemistry of 1 confirmed by X-ray crystallographic study. All of these compounds potently block osteoclastogenesis in vitro, suggesting a potential therapeutic application in prevention of osteoporosis.; Two novel rearranged trachylobane diterpenoids, designated as wallichanol A (2) and wallichanol B (3), consisting of an unprecedented pentacyclic skeleton named wallichane with a cyclobutane ring, and a new ent-trachylobane diterpenoid, 3-oxo-ent-trachyloban-17-oic acid (1), were isolated from the roots of Euphorbia wallichii. Their structures were elucidated by comprehensive analysis of 2D-NMR spectroscopic data, with the stereochemistry of 1 confirmed by X-ray crystallographic study. All of these compounds potently block osteoclastogenesis in vitro, suggesting a potential therapeutic application in prevention of osteoporosis. |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/15161 |
专题 | 中国科学院西北高原生物研究所 |
推荐引用方式 GB/T 7714 | Pan, Li,Zhou, Ping,Zhang, Xiaofeng,et al. Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii[J]. ORGANIC LETTERS, Pan Li,Zhou Ping, Zhang Xiaofeng, Peng Shulin, Ding Lisheng,Qiu Samuel X.Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii.ORGANIC LETTERS,2006,8(13):2775-2778,2006. |
APA | Pan, Li,Zhou, Ping,Zhang, Xiaofeng,Peng, Shulin,Ding, Lisheng,&Qiu, Samuel X..(2006).Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii.ORGANIC LETTERS. |
MLA | Pan, Li,et al."Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii".ORGANIC LETTERS (2006). |
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