Knowledge Management System of Northwest Institute of Plateau Biology, CAS
| Functional Evolution of Leptin of Ochotona curzoniae in Adaptive Thermogenesis Driven by Cold Environmental Stress | |
| Yang, Jie1; Bromage, Timothy G.2; Zhao, Qian3; Xu, Bao Hong4; Gao, Wei Li4; Tian, Hui Fang4; Tang, Hui Jun1; Liu, Dian Wu1; Zhao, Xin Quan5 | |
| 2011-06-16 | |
| 发表期刊 | PLOS ONE
 |
| ISSN | 1932-6203 |
| 卷号 | 6期号:6 |
| 文章类型 | Article |
| 摘要 | Background: Environmental stress can accelerate the directional selection and evolutionary rate of specific stress-response proteins to bring about new or altered functions, enhancing an organism's fitness to challenging environments. Plateau pika (Ochotona curzoniae), an endemic and keystone species on Qinghai-Tibetan Plateau, is a high hypoxia and low temperature tolerant mammal with high resting metabolic rate and non-shivering thermogenesis to cope in this harsh plateau environment. Leptin is a key hormone related to how these animals regulate energy homeostasis. Previous molecular evolutionary analysis helped to generate the hypothesis that adaptive evolution of plateau pika leptin may be driven by cold stress. Methodology/Principal Findings: To test the hypothesis, recombinant pika leptin was first purified. The thermogenic characteristics of C57BL/6J mice injected with pika leptin under warm (23+/-1 degrees C) and cold (5+/-1 degrees C) acclimation is investigated. Expression levels of genes regulating adaptive thermogenesis in brown adipose tissue and the hypothalamus are compared between pika leptin and human leptin treatment, suggesting that pika leptin has adaptively and functionally evolved. Our results show that pika leptin regulates energy homeostasis via reduced food intake and increased energy expenditure under both warm and cold conditions. Compared with human leptin, pika leptin demonstrates a superior induced capacity for adaptive thermogenesis, which is reflected in a more enhanced beta-oxidation, mitochondrial biogenesis and heat production. Moreover, leptin treatment combined with cold stimulation has a significant synergistic effect on adaptive thermogenesis, more so than is observed with a single cold exposure or single leptin treatment. Conclusions/Significance: These findings support the hypothesis that cold stress has driven the functional evolution of plateau pika leptin as an ecological adaptation to the Qinghai-Tibetan Plateau.; Background: Environmental stress can accelerate the directional selection and evolutionary rate of specific stress-response proteins to bring about new or altered functions, enhancing an organism's fitness to challenging environments. Plateau pika (Ochotona curzoniae), an endemic and keystone species on Qinghai-Tibetan Plateau, is a high hypoxia and low temperature tolerant mammal with high resting metabolic rate and non-shivering thermogenesis to cope in this harsh plateau environment. Leptin is a key hormone related to how these animals regulate energy homeostasis. Previous molecular evolutionary analysis helped to generate the hypothesis that adaptive evolution of plateau pika leptin may be driven by cold stress. |
| WOS标题词 | Science & Technology |
| 关键词[WOS] | BROWN ADIPOSE-TISSUE ; MESSENGER-RNA EXPRESSION ; PPAR-GAMMA ; ADIPOCYTE DIFFERENTIATION ; ENERGY-METABOLISM ; RECEPTOR-ALPHA ; RECRUITMENT ; PGC-1-ALPHA ; SYSTEM ; UCP1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000291734100001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://210.75.249.4/handle/363003/1536 |
| 专题 | 中国科学院西北高原生物研究所 |
| 作者单位 | 1.Hebei Med Univ, Sch Publ Hlth, Dept Epidemiol & Stat, Shijiazhuang, Hebei, Peoples R China 2.NYU, Coll Dent, Dept Basic Sci & Craniofacial Biol, Dept Biomat & Biomimet, New York, NY USA 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 4.Shijiazhuang Ctr Dis Control & Prevent, Dept Microbiol, Shijiazhuang, Hebei, Peoples R China 5.Chinese Acad Sci, NW Plateau Inst Biol, Key Lab Qinghai Tibetan Plateau Biol Evolut & Ada, Xining, Qinghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Jie,Bromage, Timothy G.,Zhao, Qian,et al. Functional Evolution of Leptin of Ochotona curzoniae in Adaptive Thermogenesis Driven by Cold Environmental Stress[J]. PLOS ONE,2011,6(6). |
| APA | Yang, Jie.,Bromage, Timothy G..,Zhao, Qian.,Xu, Bao Hong.,Gao, Wei Li.,...&Zhao, Xin Quan.(2011).Functional Evolution of Leptin of Ochotona curzoniae in Adaptive Thermogenesis Driven by Cold Environmental Stress.PLOS ONE,6(6). |
| MLA | Yang, Jie,et al."Functional Evolution of Leptin of Ochotona curzoniae in Adaptive Thermogenesis Driven by Cold Environmental Stress".PLOS ONE 6.6(2011). |
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