NWIPB OpenIR
Domestication Relaxed Selective Constraints on the Yak Mitochondrial Genome
Wang, Zhaofeng1; Yonezawa, Takahiro2; Liu, Bin3,4; Ma, Tao1; Shen, Xin5; Su, Jianping6; Guo, Songchang6; Hasegawa, Masami2; Liu, Jianquan1
2011-05-01
发表期刊MOLECULAR BIOLOGY AND EVOLUTION
ISSN0737-4038
卷号28期号:5页码:1553-1556
文章类型Article
摘要Wild yaks roaming in the high-altitude Qinghai-Tibetan plateau have to maintain high metabolic efficiency. However, domestic yaks do not require such high efficiency because of their limited activity. Hence, domestication may have caused the relaxation of selective constraints on the yak mitochondrial genome because mitochondrial mutations are extremely sensitive to energy-related selective pressures. We have tested this hypothesis by analyzing the mitochondrial genomes of 51 domestic yaks and 21 wild yaks. The results show that the ratio of nonsynonymous/synonymous substitutions in mitochondrial protein-coding genes is significantly higher in domestic yak lineages than those of wild yaks. This genetic difference suggests that the relaxation of selective constraints following the domestication in addition to bottlenecks has allowed faster accumulation of nonsilent substitutions in the yak mitochondrial genome, despite its short domestication history.; Wild yaks roaming in the high-altitude Qinghai-Tibetan plateau have to maintain high metabolic efficiency. However, domestic yaks do not require such high efficiency because of their limited activity. Hence, domestication may have caused the relaxation of selective constraints on the yak mitochondrial genome because mitochondrial mutations are extremely sensitive to energy-related selective pressures. We have tested this hypothesis by analyzing the mitochondrial genomes of 51 domestic yaks and 21 wild yaks. The results show that the ratio of nonsynonymous/synonymous substitutions in mitochondrial protein-coding genes is significantly higher in domestic yak lineages than those of wild yaks. This genetic difference suggests that the relaxation of selective constraints following the domestication in addition to bottlenecks has allowed faster accumulation of nonsilent substitutions in the yak mitochondrial genome, despite its short domestication history.
关键词Bos Grunniens Domestication Mitochondrial Genome Evolution
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]DELETERIOUS MUTATIONS ; RATE RATIO ; DNA ; EVOLUTION ; DOG ; ACCUMULATION ; GENES
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS类目Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS记录号WOS:000289841500002
引用统计
被引频次:69[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/1550
专题中国科学院西北高原生物研究所
作者单位1.Lanzhou Univ, Mol Ecol Grp, Key Lab Arid & Grassland Ecol, Lanzhou, Gansu, Peoples R China
2.Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China
3.Chinese Acad Sci, Xinjiang Inst Ecol & Geog, Urumqi, Xinjiang, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Qingdao, Shandong, Peoples R China
5.Chinese Acad Sci, Beijing Genom Inst, Beijing, Peoples R China
6.Chinese Acad Sci, Key Lab Adaptat & Evolut Plateau Biota, NW Inst Plateau Biol, Xining, Qinghai, Peoples R China
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GB/T 7714
Wang, Zhaofeng,Yonezawa, Takahiro,Liu, Bin,et al. Domestication Relaxed Selective Constraints on the Yak Mitochondrial Genome[J]. MOLECULAR BIOLOGY AND EVOLUTION,2011,28(5):1553-1556.
APA Wang, Zhaofeng.,Yonezawa, Takahiro.,Liu, Bin.,Ma, Tao.,Shen, Xin.,...&Liu, Jianquan.(2011).Domestication Relaxed Selective Constraints on the Yak Mitochondrial Genome.MOLECULAR BIOLOGY AND EVOLUTION,28(5),1553-1556.
MLA Wang, Zhaofeng,et al."Domestication Relaxed Selective Constraints on the Yak Mitochondrial Genome".MOLECULAR BIOLOGY AND EVOLUTION 28.5(2011):1553-1556.
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