Dual-Sensitive Probe of 2-(Benzoacridin)ethyl-imidazole-1-carboxylate for Determination of Aliphatic Amine with Fluorescence and Online Atmospheric Pressure Chemical Ionization Mass Spectrometry Identification

NWIPB OpenIR

	Dual-Sensitive Probe of 2-(Benzoacridin)ethyl-imidazole-1-carboxylate for Determination of Aliphatic Amine with Fluorescence and Online Atmospheric Pressure Chemical Ionization Mass Spectrometry Identification
	FU Yan-Yan ; LI Xiao-Yan ; SUN Zhi-Wei ; QIN Xue-Qin ; XIA Lian ; SUO You-Rui ; LI Yu-Lin ; You JM(尤进茂)
	2010
发表期刊	Chinese Journal of Analytical Chemistry ; FU Yan-Yan;LI Xiao-Yan;SUN Zhi-Wei;QIN Xue-Qin;XIA Lian;SUO You-Rui;LI Yu-Lin;尤进茂.Dual-Sensitive Probe of 2-(Benzoacridin)ethyl-imidazole-1-carboxylate for Determination of Aliphatic Amine with Fluorescence and Online Atmospheric Pressure Chemical Ionization Mass Spectrometry Identification,Chinese Journal of Analytical Chemistry,2010,38(1):8-12
摘要	Using three different derivatization methods to mark the amine compounds, we compared the difference of derivatization efficiency and gave the optimal method. 5-(2-Hydroxyethyl)benzoacridine reacts with coupling agent N,N′-carbonyldiimidazole (CDI) to form an activated amide intermediate 2-(benzoacridin)ethyl-imidazole-1-carboxylate (BAEIC). BAEIC, which is dual-sensitive probe, reacts preferably with amino compounds at 80 °C in the presence of 4-dimethylaminopyridine (DMAP) catalyst in N,N-dimethylformamide (DMF) solvent to give the corresponding sensitively fluorescent derivatives with an excitation maximum at 280 nm of λex and an emission maximum at 510 nm of λem. BAEIC-amine derivatives simultaneously exhibited high-ionization potential with percent ionization δ changing from 5.62% to 58.08% in aqueous acetonitrile and from 2.14% to 56.58% in aqueous methanol. Derivatives are not only sensitive to fluorescence but also to MS ionizable potential. The fluorescence detection limits are 0.12–0.59 ng mL？1 (at a signal-to-noise ratio of 3). The online Atmospheric Pressure Chemical Ionization Mass Spectrometry (APCI-MS) detection limits are 1.89–14.12 ng mL？1 (at a signal-to-noise ratio of 5).
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/15587
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	FU Yan-Yan,LI Xiao-Yan,SUN Zhi-Wei,et al. Dual-Sensitive Probe of 2-(Benzoacridin)ethyl-imidazole-1-carboxylate for Determination of Aliphatic Amine with Fluorescence and Online Atmospheric Pressure Chemical Ionization Mass Spectrometry Identification[J]. Chinese Journal of Analytical Chemistry, FU Yan-Yan;LI Xiao-Yan;SUN Zhi-Wei;QIN Xue-Qin;XIA Lian;SUO You-Rui;LI Yu-Lin;尤进茂.Dual-Sensitive Probe of 2-(Benzoacridin)ethyl-imidazole-1-carboxylate for Determination of Aliphatic Amine with Fluorescence and Online Atmospheric Pressure Chemical Ionization Mass Spectrometry Identification,Chinese Journal of Analytical Chemistry,2010,38(1):8-12,2010.
APA	FU Yan-Yan.,LI Xiao-Yan.,SUN Zhi-Wei.,QIN Xue-Qin.,XIA Lian.,...&尤进茂.(2010).Dual-Sensitive Probe of 2-(Benzoacridin)ethyl-imidazole-1-carboxylate for Determination of Aliphatic Amine with Fluorescence and Online Atmospheric Pressure Chemical Ionization Mass Spectrometry Identification.Chinese Journal of Analytical Chemistry.
MLA	FU Yan-Yan,et al."Dual-Sensitive Probe of 2-(Benzoacridin)ethyl-imidazole-1-carboxylate for Determination of Aliphatic Amine with Fluorescence and Online Atmospheric Pressure Chemical Ionization Mass Spectrometry Identification".Chinese Journal of Analytical Chemistry (2010).