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Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles
Zhang, Yaqin ; Liu, Bin ; Wu, Heming ; Li, Bin ; Xu, Junyong ; Duan, Lei ; Jiang, Caiyun ; Zhao, Xiaohui ; Yuan, Yi ; Zhang, Gen ; Zeng, Xin
2014-12-01
发表期刊JOURNAL OF BIOMEDICAL NANOTECHNOLOGY ; Zhang, YQ; Liu, B; Wu, HM; Li, B; Xu, JY; Duan, L; Jiang, CY; Zhao, XH; Yuan, Y; Zhang, G; Zeng, X.Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles,JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2014,10(12):3638
摘要Verbascoside (VB), a major bioactive constituent of the Tsoong herb, has attracted a great deal of attention due to its pharmacological properties. In this study, we demonstrated the inhibitory effect of VB-loaded gold nanoparticles (VB-Au) on the growth of K562 cells both in vitro and in vivo. We found that, in contrast with the same concentration of gold nanoparticles (Au) or VB, VB-Au significantly decreased the viability of K562 cells and promoted the apoptosis of tumor cells. A tumor implantation mouse model further showed that the intravenous injection of VB-Au effectively inhibited the growth and induced the apoptosis of tumor cells. In conclusion, our results collectively demonstrate that VB-Au nanoparticles provide an effective strategy to control tumor cell growth.; Verbascoside (VB), a major bioactive constituent of the Tsoong herb, has attracted a great deal of attention due to its pharmacological properties. In this study, we demonstrated the inhibitory effect of VB-loaded gold nanoparticles (VB-Au) on the growth of K562 cells both in vitro and in vivo. We found that, in contrast with the same concentration of gold nanoparticles (Au) or VB, VB-Au significantly decreased the viability of K562 cells and promoted the apoptosis of tumor cells. A tumor implantation mouse model further showed that the intravenous injection of VB-Au effectively inhibited the growth and induced the apoptosis of tumor cells. In conclusion, our results collectively demonstrate that VB-Au nanoparticles provide an effective strategy to control tumor cell growth.
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/16941
专题中国科学院西北高原生物研究所
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GB/T 7714
Zhang, Yaqin,Liu, Bin,Wu, Heming,et al. Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, Zhang, YQ; Liu, B; Wu, HM; Li, B; Xu, JY; Duan, L; Jiang, CY; Zhao, XH; Yuan, Y; Zhang, G; Zeng, X.Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles,JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2014,10(12):3638,2014.
APA Zhang, Yaqin.,Liu, Bin.,Wu, Heming.,Li, Bin.,Xu, Junyong.,...&Zeng, Xin.(2014).Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY.
MLA Zhang, Yaqin,et al."Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2014).
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