Protective effect of seed oil of Herpetospermum pedunculosum against carbon tetrachloride-induced liver injury in rats

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	Protective effect of seed oil of Herpetospermum pedunculosum against carbon tetrachloride-induced liver injury in rats
	Li, Gang ; Wang, Xiao-Yan ; Suo, You-Rui ; Wang, Hong-Lun
	2014-09-01
发表期刊	SAUDI MEDICAL JOURNAL ; Li, G; Wang, XY; Suo, YR; Wang, HL.Protective effect of seed oil of Herpetospermum pedunculosum against carbon tetrachloride-induced liver injury in rats,SAUDI MEDICAL JOURNAL,2014,35(9):981
摘要	Objectives: To investigate the protective effect of Herpetospermum pedunculosum (H. pedunculosum) seed oil against carbon tetrachloride (CCl4)-induced liver damage. Methods: This experimental study was conducted at the Northwest Institute of Plateau Biology, Chinese Academy of Sciences, and Yantai University, China from November 2012 to May 2013. The H. pedunculosum seed oil was extracted using supercritical carbon dioxide. The antioxidant activities of H. pedunculosum seed oil were assayed in vitro by 2,2-diphenyl-1-picrylhydrazyl assay, lipid peroxidation assay, and antihemolytic assay. Adult Sprague Dawley rats were randomly divided into 6 groups (10 rats/group) including control, CCl4, CCl4+bifendate, and CCl4+H. pedunculosum seed oil (3 different doses) groups. Results: The CCl4-induced liver lesions include hepatocyte necrosis, ballooning degeneration, calcification, and fibrosis. Moreover, CCl4 damage results in an obvious increase of serum triglycerides, high-density lipoprotein, low-density lipoprotein, malondialdehyde, total bilirubin, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activity. In addition, CCl4 also significantly decreased the activities of superoxide dismutase (SOD). By contrast, H. pedunculosum seed oil administration significantly ameliorated the CCl4 induced liver lesions, lowered the serum levels of hepatic enzyme markers, and increased the activities of SOD. Conclusion: The results of this study show that H. pedunculosum seed oil can be proposed to protect the liver against CCl4-induced oxidative damage in rats, and the hepatoprotective effect might be correlated with its potent antioxidant and free radical scavenging effect.; Objectives: To investigate the protective effect of Herpetospermum pedunculosum (H. pedunculosum) seed oil against carbon tetrachloride (CCl4)-induced liver damage.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/16959
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Li, Gang,Wang, Xiao-Yan,Suo, You-Rui,et al. Protective effect of seed oil of Herpetospermum pedunculosum against carbon tetrachloride-induced liver injury in rats[J]. SAUDI MEDICAL JOURNAL, Li, G; Wang, XY; Suo, YR; Wang, HL.Protective effect of seed oil of Herpetospermum pedunculosum against carbon tetrachloride-induced liver injury in rats,SAUDI MEDICAL JOURNAL,2014,35(9):981,2014.
APA	Li, Gang,Wang, Xiao-Yan,Suo, You-Rui,&Wang, Hong-Lun.(2014).Protective effect of seed oil of Herpetospermum pedunculosum against carbon tetrachloride-induced liver injury in rats.SAUDI MEDICAL JOURNAL.
MLA	Li, Gang,et al."Protective effect of seed oil of Herpetospermum pedunculosum against carbon tetrachloride-induced liver injury in rats".SAUDI MEDICAL JOURNAL (2014).