Synthesis and antimicrobial activities of novel peptide deformylase inhibitors

NWIPB OpenIR

	Synthesis and antimicrobial activities of novel peptide deformylase inhibitors
	Yin, Ling 1; Xu, Wei-Ren 2; Wang, Zhi-Guo 3; Zhang, Da-Tong 1; Jia, Jiong 1; Ge, Yan-Qing 1; Li, Yan 1; Wang, Jian-Wu 1
	2010
发表期刊	ARKIVOC
ISSN	1551-7004
页码	196-205
文章类型	Article
摘要	A new series of N-formylhydroxylamine compounds were designed, optimized with the AutoDock 4.0.1 to investigate the interactions between the target compounds and the amino acid residues of the Escherichia coli PDF center dot Ni enzyme, and then synthesized through multi-step sequence starting from diethyl malonate. The structures of the compounds were characterized on the basis of spectral (FT-IR, 1H NMR and mass) analysis. All the synthesized compounds have been screened for their antimicrobial activities. It was found that the compounds 11c, 11d, 11f and 11g exhibited potent inhibitory activity against S. aureus in vitro.; A new series of N-formylhydroxylamine compounds were designed, optimized with the AutoDock 4.0.1 to investigate the interactions between the target compounds and the amino acid residues of the Escherichia coli PDF center dot Ni enzyme, and then synthesized through multi-step sequence starting from diethyl malonate. The structures of the compounds were characterized on the basis of spectral (FT-IR, 1H NMR and mass) analysis. All the synthesized compounds have been screened for their antimicrobial activities. It was found that the compounds 11c, 11d, 11f and 11g exhibited potent inhibitory activity against S. aureus in vitro.
关键词	Peptide Deformylase Inhibitors N-formylhydroxylamine Compounds Antibacterial Activity
WOS标题词	Science & Technology ; Physical Sciences
关键词[WOS]	TARGET ; BB-3497 ; PROTEIN
收录类别	SCI
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000282479700019
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/1784
专题	中国科学院西北高原生物研究所
作者单位	1.Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China 2.Pharmaceut Res Inst, Tianjin 300193, Peoples R China 3.Chinese Acad Sci, NW Inst Plateau Biol, Xining 810001, Peoples R China
推荐引用方式 GB/T 7714	Yin, Ling,Xu, Wei-Ren,Wang, Zhi-Guo,et al. Synthesis and antimicrobial activities of novel peptide deformylase inhibitors[J]. ARKIVOC,2010:196-205.
APA	Yin, Ling.,Xu, Wei-Ren.,Wang, Zhi-Guo.,Zhang, Da-Tong.,Jia, Jiong.,...&Wang, Jian-Wu.(2010).Synthesis and antimicrobial activities of novel peptide deformylase inhibitors.ARKIVOC,196-205.
MLA	Yin, Ling,et al."Synthesis and antimicrobial activities of novel peptide deformylase inhibitors".ARKIVOC (2010):196-205.