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ZNF536, a Novel Zinc Finger Protein Specifically Expressed in the Brain, Negatively Regulates Neuron Differentiation by Repressing Retinoic Acid-Induced Gene Transcription
Qin, Zhen1; Ren, Fangli1; Xu, Xialian1; Ren, Yongming1; Li, Hongge2,3; Wang, Yinyin1; Zhai, Yonggong4; Chang, Zhijie1
2009-07-01
发表期刊MOLECULAR AND CELLULAR BIOLOGY
ISSN0270-7306
卷号29期号:13页码:3633-3643
文章类型Article
摘要Neuronal differentiation is tightly regulated by a variety of factors. In a search for neuron-specific genes, we identified a highly conserved novel zinc finger protein, ZNF536. We observed that ZNF536 is most abundant in the brain and, in particular, is expressed in the developing central nervous system and dorsal root ganglia and localized in the cerebral cortex, hippocampus, and hypothalamic area. During neuronal differentiation of P19 cells induced by retinoic acid (RA), ZNF536 expression is increased at an early stage, and it is maintained at a constant level in later stages. Overexpression of ZNF536 results in an inhibition of RA-induced neuronal differentiation, while depletion or mutation of the ZNF536 gene results in an enhancement of differentiation. We further demonstrated that ZNF536 inhibits expression of neuron-specific marker genes, possibly through the inhibition of RA response element-mediated transcriptional activity, as overexpression of RA receptor alpha can rescue the inhibitory role of ZNF536 in neuronal differentiation and neuron-specific gene expression. Our studies have identified a novel zinc finger protein that negatively regulates neuron differentiation.; Neuronal differentiation is tightly regulated by a variety of factors. In a search for neuron-specific genes, we identified a highly conserved novel zinc finger protein, ZNF536. We observed that ZNF536 is most abundant in the brain and, in particular, is expressed in the developing central nervous system and dorsal root ganglia and localized in the cerebral cortex, hippocampus, and hypothalamic area. During neuronal differentiation of P19 cells induced by retinoic acid (RA), ZNF536 expression is increased at an early stage, and it is maintained at a constant level in later stages. Overexpression of ZNF536 results in an inhibition of RA-induced neuronal differentiation, while depletion or mutation of the ZNF536 gene results in an enhancement of differentiation. We further demonstrated that ZNF536 inhibits expression of neuron-specific marker genes, possibly through the inhibition of RA response element-mediated transcriptional activity, as overexpression of RA receptor alpha can rescue the inhibitory role of ZNF536 in neuronal differentiation and neuron-specific gene expression. Our studies have identified a novel zinc finger protein that negatively regulates neuron differentiation.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]EMBRYONAL CARCINOMA-CELLS ; NUCLEAR RECEPTOR TLX ; STEM-CELLS ; IDENTIFICATION ; MECHANISMS ; BIOLOGY ; ZNF219 ; FAMILY ; GROWTH
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
WOS类目Biochemistry & Molecular Biology ; Cell Biology
WOS记录号WOS:000266978000015
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/1852
专题中国科学院西北高原生物研究所
作者单位1.Tsinghua Univ, Dept Biol Sci & Biotechnol, Sch Med, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China
2.Chinese Acad Sci, NW Plateau Inst Biol, Xining, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
4.Beijing Normal Univ, Coll Life Sci, Beijing 100875, Peoples R China
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Qin, Zhen,Ren, Fangli,Xu, Xialian,et al. ZNF536, a Novel Zinc Finger Protein Specifically Expressed in the Brain, Negatively Regulates Neuron Differentiation by Repressing Retinoic Acid-Induced Gene Transcription[J]. MOLECULAR AND CELLULAR BIOLOGY,2009,29(13):3633-3643.
APA Qin, Zhen.,Ren, Fangli.,Xu, Xialian.,Ren, Yongming.,Li, Hongge.,...&Chang, Zhijie.(2009).ZNF536, a Novel Zinc Finger Protein Specifically Expressed in the Brain, Negatively Regulates Neuron Differentiation by Repressing Retinoic Acid-Induced Gene Transcription.MOLECULAR AND CELLULAR BIOLOGY,29(13),3633-3643.
MLA Qin, Zhen,et al."ZNF536, a Novel Zinc Finger Protein Specifically Expressed in the Brain, Negatively Regulates Neuron Differentiation by Repressing Retinoic Acid-Induced Gene Transcription".MOLECULAR AND CELLULAR BIOLOGY 29.13(2009):3633-3643.
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