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Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation
Bao, Qi ; Li, Chong ; Xu, Chongfeng ; Zhang, Ruiying ; Zhao, Kai ; Duan, Ziyuan
2018-03-10
发表期刊GENE
摘要Porcine butyrophilin-like 5 (Btnl5) is a novel member of the butyrophilin family, which consists of immune regulators. The expression pattern and the function of this gene remain unclear. In this study, Btnl5 is identified as a negative regulator of the NF-kappa B pathway. Our study indicates that Btnl5 is mainly expressed in intestinal epithelial cells (IECs) and expressed in membrane systems. Btnl5 inhibits MyD88-mediated activation of the NF-kappa B pathway. Btnl5 interacts with TNF receptor-associated factor 2 (TRAF2) and transcription factor p65. Besides, Btnl5 inhibits p65-mediated activation of the NF-kappa B pathway and inhibits nuclear translocation of p65. These results suggest that Btnl5 may inhibit NF-kappa B pathway through binding and interfere nuclear translocation of p65.
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/18721
专题中国科学院西北高原生物研究所
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GB/T 7714
Bao, Qi,Li, Chong,Xu, Chongfeng,et al. Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation[J]. GENE,2018.
APA Bao, Qi,Li, Chong,Xu, Chongfeng,Zhang, Ruiying,Zhao, Kai,&Duan, Ziyuan.(2018).Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation.GENE.
MLA Bao, Qi,et al."Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation".GENE (2018).
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