NWIPB OpenIR
Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells
Xia, Zhenjiang ; Wei, Lixin ; Du, Yuzhi ; Wang, Lulu ; Han, Jichun ; He, Qiangqiang ; Chen, Haijuan ; Zou, Xiaoyan ; Wu, Huali ; Shang, Jing
2018-08-01
Source PublicationCHEMICAL & PHARMACEUTICAL BULLETIN
AbstractZuotai is a drug containing mercury considered to be the king of Tibetan medicine. The biosafety of Zuotai led people's attention and so far little is known about the toxicity of Zuotai to mast cells. RBL-2H3 cells which used as an alternative model of mast cells were treated with Zuotai, beta-HgS and positive drug Compound 48/80 respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the toxicity of drugs to RBL-2H3 cells. The degranulation of RBL-2H3 cells was studied from beta-hexosaminidase, histamine, interleukin (IL)-4 and tumor necrosis factor-alpha (TNF-alpha). The result showed that Zuotai can affect the cytotoxicity and degranulation of RBL-2H3 cells and the results can provide reference for the toxicity evaluations of Tibetan medicine Zuotai.
PublisherPHARMACEUTICAL SOC JAPAN
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/18913
Collection中国科学院西北高原生物研究所
Recommended Citation
GB/T 7714
Xia, Zhenjiang,Wei, Lixin,Du, Yuzhi,et al. Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2018.
APA Xia, Zhenjiang.,Wei, Lixin.,Du, Yuzhi.,Wang, Lulu.,Han, Jichun.,...&Shang, Jing.(2018).Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells.CHEMICAL & PHARMACEUTICAL BULLETIN.
MLA Xia, Zhenjiang,et al."Effect of the Tibetan Medicine Zuotai on Degranulation and Inflammatory Mediator Release in RBL-2H3 Cells".CHEMICAL & PHARMACEUTICAL BULLETIN (2018).
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