Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii

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	Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii
	Pan, Li ; Zhou, Ping ; Zhang, Xiaofeng ; Peng, Shulin ; Ding, Lisheng ; Qiu, Samuel X.
	2006-06-22
发表期刊	ORGANIC LETTERS ; Pan Li,Zhou Ping, Zhang Xiaofeng, Peng Shulin, Ding Lisheng,Qiu Samuel X.Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii.ORGANIC LETTERS,2006,8(13):2775-2778
摘要	Two novel rearranged trachylobane diterpenoids, designated as wallichanol A (2) and wallichanol B (3), consisting of an unprecedented pentacyclic skeleton named wallichane with a cyclobutane ring, and a new ent-trachylobane diterpenoid, 3-oxo-ent-trachyloban-17-oic acid (1), were isolated from the roots of Euphorbia wallichii. Their structures were elucidated by comprehensive analysis of 2D-NMR spectroscopic data, with the stereochemistry of 1 confirmed by X-ray crystallographic study. All of these compounds potently block osteoclastogenesis in vitro, suggesting a potential therapeutic application in prevention of osteoporosis.; Two novel rearranged trachylobane diterpenoids, designated as wallichanol A (2) and wallichanol B (3), consisting of an unprecedented pentacyclic skeleton named wallichane with a cyclobutane ring, and a new ent-trachylobane diterpenoid, 3-oxo-ent-trachyloban-17-oic acid (1), were isolated from the roots of Euphorbia wallichii. Their structures were elucidated by comprehensive analysis of 2D-NMR spectroscopic data, with the stereochemistry of 1 confirmed by X-ray crystallographic study. All of these compounds potently block osteoclastogenesis in vitro, suggesting a potential therapeutic application in prevention of osteoporosis.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/20257
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Pan, Li,Zhou, Ping,Zhang, Xiaofeng,et al. Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii[J]. ORGANIC LETTERS, Pan Li,Zhou Ping, Zhang Xiaofeng, Peng Shulin, Ding Lisheng,Qiu Samuel X.Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii.ORGANIC LETTERS,2006,8(13):2775-2778,2006.
APA	Pan, Li,Zhou, Ping,Zhang, Xiaofeng,Peng, Shulin,Ding, Lisheng,&Qiu, Samuel X..(2006).Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii.ORGANIC LETTERS.
MLA	Pan, Li,et al."Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii".ORGANIC LETTERS (2006).