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Determination of parabens in domestic sewage by isotope-coded derivatization coupled with high performance liquid chromatography-tandem mass spectrometry
Che, Dandan ; Sun, Zhiwei ; Cheng, Jie ; Dou, Kun ; Ji, Zhongyin ; Chen, Guang ; Li, Guoliang ; You, Jinmao
2017
发表期刊MICROCHEMICAL JOURNAL
摘要We have established an isotope labeling protocol for determining parabens in wastewater, based on a pair of isotope-coded derivatization reagents, by high performance liquid chromatography (LC) and electrospray mass spectrometry (ESI-MS). The pair of reagents used in our work were d(0)-10-methylacridone-2-sulfonyl chloride (d(0)-MASC, light form) and d(3)-10-methylacridone-2-sulfonyl chloride (d(3)-MASC, heavy form). d(0)-MASC and d(3)-MASC could easily derivatize parabens at 55 degrees C for 7.5 min in the mixture of bicarbonate and acetonitrile (1:1 v/v). It is shown that the derivatization offers 1-2 orders of magnitude signal enhancement over underivatized counterparts. The global isotope internal standard technology was employed for quantification analysis with d(3)-MASC-paraben as internal standard for corresponding d(0)-MASC-paraben. In addition, homologous internal standard was simultaneously used to correct derivatization processes. The obtained double internal standard calibration curves for parabens were linear over the range of 1-500 nmol L-1 (r > 0.997). The isotope coded derivatization based quantification method was precise and practical with RSD <= 3.6% and accuracy ranged 96.5 to 104.7%. The proposed method has also been successfully applied to the quantification of parabens in domestic sewage samples with precisions <= 5.2% and recoveries >= 87.9%. Five kinds of paraben including methylparaben, ethylparaben, propylparaben, butylparaben, and benzylparaben were detected in the tested samples. The quantitative results indicated that parabens were at nmol L-1 level or lower, and ethylparaben were the most abundant, followed by methylparaben, propylparaben and butylparaben. It has been demonstrated that the isotope-coded derivatization reagents are useful for accurate quantification of analytes having target functional groups in real samples. (C) 2016 Elsevier B.V. All rights reserved.
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/22862
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Che, Dandan,Sun, Zhiwei,Cheng, Jie,et al. Determination of parabens in domestic sewage by isotope-coded derivatization coupled with high performance liquid chromatography-tandem mass spectrometry[J]. MICROCHEMICAL JOURNAL,2017.
APA Che, Dandan.,Sun, Zhiwei.,Cheng, Jie.,Dou, Kun.,Ji, Zhongyin.,...&You, Jinmao.(2017).Determination of parabens in domestic sewage by isotope-coded derivatization coupled with high performance liquid chromatography-tandem mass spectrometry.MICROCHEMICAL JOURNAL.
MLA Che, Dandan,et al."Determination of parabens in domestic sewage by isotope-coded derivatization coupled with high performance liquid chromatography-tandem mass spectrometry".MICROCHEMICAL JOURNAL (2017).
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