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Safety investigation on total steroid saponins extracts from Dioscorea zingiberensis CH Wright: Sub-acute and chronic toxicity studies on dogs
Zhang, Xinxin1; Jin, Ming1; Tadesse, Nigatu2; Xian, Liang1; Zhang, Hui1; Wang, Sicen1; Dang, Jun3; Zhang, Yan4; Guo, Zengjun1; Ito, Yoichiro5
2017-12-01
Source PublicationREGULATORY TOXICOLOGY AND PHARMACOLOGY
AbstractSub-acute and chronic toxic effects of total steroidal saponins (TSSN) extracts from Dioscorea zingiberensis C.H. Wright on various internal organs and biochemical indicators have never been studied before and this study is the first of its kind to demonstrate sub-acute and chronic toxicities of TSSN on dogs. Administration of TSSN extracts at doses up to 3000 mg/Kg daily for 14 days, no biochemical and organ changes were observed on the experimental groups of dogs. Further, chronic toxicity study through oral administration of TSSN extracts at the gradual doses of 50, 250 and 500 mg/Kg for 90 days followed by a 2-week recovery assay revealed absence of significant architectural and morphological changes in internal organs which were confirmed through histopathological examination and merely no significant alteration in the biochemical indicators including hematologic and urine analysis and electrocardiogram compared to the control dogs. This toxicological evaluation came across with the finding that the herbal preparation can be considered as nontoxic and animals could tolerate the extracts at doses up to 500 mg/Kg with LD50 greater than 3000 mg/Kg. It may serve as a preliminary scientific evidence for further therapeutic investigations.
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/23772
Collection中国科学院西北高原生物研究所
Corresponding AuthorGuo, Zengjun; Ito, Yoichiro
Affiliation1.Xi An Jiao Tong Univ, Coll Pharm, 76 Yanta Rd, Xian 710061, Shaanxi, Peoples R China
2.Xi An Jiao Tong Univ, Sch Int Educ, Xian 710061, Shaanxi, Peoples R China
3.Chinese Acad Sci, Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining, Qinghai, Peoples R China
4.Xian Med Univ, Xian 710021, Shaanxi, Peoples R China
5.NHLBI, Lab Bioseparat Technol, Biochem & Biophys Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA
Recommended Citation
GB/T 7714
Zhang, Xinxin,Jin, Ming,Tadesse, Nigatu,et al. Safety investigation on total steroid saponins extracts from Dioscorea zingiberensis CH Wright: Sub-acute and chronic toxicity studies on dogs[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY,2017.
APA Zhang, Xinxin.,Jin, Ming.,Tadesse, Nigatu.,Xian, Liang.,Zhang, Hui.,...&Ito, Yoichiro.(2017).Safety investigation on total steroid saponins extracts from Dioscorea zingiberensis CH Wright: Sub-acute and chronic toxicity studies on dogs.REGULATORY TOXICOLOGY AND PHARMACOLOGY.
MLA Zhang, Xinxin,et al."Safety investigation on total steroid saponins extracts from Dioscorea zingiberensis CH Wright: Sub-acute and chronic toxicity studies on dogs".REGULATORY TOXICOLOGY AND PHARMACOLOGY (2017).
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