Normal diet Vs High fat diet - A comparative study: Behavioral and neuroimmunological changes in adolescent male mice.

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	Normal diet Vs High fat diet - A comparative study: Behavioral and neuroimmunological changes in adolescent male mice.
	Wu, Huali 1,2; Liu, Qiongzhen 1,3; Kalavagunta, Praveen Kumar 1,3,4; Huang, Qiaoling 1,3,4; Lv, Wenting 1,3,4; An, Xiaohong 1,3,4; Chen, Haijuan 1,5; Wang, Tao 1,3,4; Heriniaina, Rakotomalala Manda 1,3,4; Qiao, Tong 6; Shang, Jing 1,3,4,5
	2018-02-01
发表期刊	METABOLIC BRAIN DISEASE
摘要	Recent evidence has established that consumption of High-fat diet (HFD)-induced obesity is associated with deficits in hippocampus-dependent memory/learning and mood states. Nevertheless the link between obesity and emotional disorders still remains to be elucidated. This issue is of particular interest during adolescence, which is important period for shaping learning/memory and mood regulation that can be sensitive to the detrimental effects of HFD. Our present study is focused to investigate behavioral and metabolic influences of short-term HFD intake in adolescent C57BL/6 mice. HFD caused weight gain, impaired glucose tolerance (IGT) and depression-like behavior as early as after 3 weeks which was clearly proved by a decrease in number of groomings in the open field test (OFT) and an increase in immobility time in the tail suspension test (TST). In the 4th week HFD induced obese model was fully developed and above behavioral symptoms were more dominant (decrease in number of crossings and groomings and increase in immobility time in both FST and TST). At the end of 6th week hippocampal analysis revealed the differences in morphology (reduced Nissl positive neurons and decreased the 5-HT1A receptor expression), neuronal survival (increased cleaved caspase-3 expression), synaptic plasticity (down regulation of p-CREB and BDNF), and inflammatory responses (increase in expression of pro-inflammatory cytokines and decrease in expression of anti-inflammatory cyokines) in HFD mice. Our results demonstrate that, high-fat feeding of adolescent mice could provoke "depression-like" behavior as early as 3 weeks and modulate structure, neuron survival and neuroinflammation in hippocampus as early as 6 weeks proving that adolescent age is much prone to adverse effects of HFD, which causes obesity, behavioral differences, memory and learning deficiencies.
出版者	SPRINGER/PLENUM PUBLISHERS
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/23776
专题	中国科学院西北高原生物研究所
通讯作者	Qiao, Tong; Shang, Jing
作者单位	1.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China 2.China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Jiangsu, Peoples R China 3.China Pharmaceut Univ, Jiangsu Key Lab TCM Evaluat & Translat Res, Nanjing 211198, Jiangsu, Peoples R China 4.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 211198, Jiangsu, Peoples R China 5.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining 810008, Qinghai, Peoples R China 6.Nanjing Drum Tower Hosp, Dept Vasc Surg, Nanjing 210008, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Wu, Huali,Liu, Qiongzhen,Kalavagunta, Praveen Kumar,et al. Normal diet Vs High fat diet - A comparative study: Behavioral and neuroimmunological changes in adolescent male mice.[J]. METABOLIC BRAIN DISEASE,2018.
APA	Wu, Huali.,Liu, Qiongzhen.,Kalavagunta, Praveen Kumar.,Huang, Qiaoling.,Lv, Wenting.,...&Shang, Jing.(2018).Normal diet Vs High fat diet - A comparative study: Behavioral and neuroimmunological changes in adolescent male mice..METABOLIC BRAIN DISEASE.
MLA	Wu, Huali,et al."Normal diet Vs High fat diet - A comparative study: Behavioral and neuroimmunological changes in adolescent male mice.".METABOLIC BRAIN DISEASE (2018).