Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia

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	Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia
	Yang, Fang ; Suo, Yourui ; Chen, Dongli ; Tong, Li
	2016-06-01
发表期刊	BIOSCIENCE TRENDS
摘要	Chronic hyperlipemia increases the incidence of vascular endothelial dysfunction and can even induce cardiovascular disease. Sea buckthorn contains a host of bioactives such as flavonoids and polyphenols that can prevent the development of cardiovascular disease. The current study isolated active ingredients, polyphenols, from sea buckthorn berries (SVP) and orally administered SVP at a dose of 7-28 mg/kg. This treatment significantly reduced serum lipids, it enhanced the activity of antioxidant enzymes, and it decreased the level of serum TNF-alpha and IL-6. SVP also alleviate vascular impairment by decreasing the expression of eNOS, ICAM-1, and LOX-1 mRNA and proteins in aortas of rats with hyperlipidemia. Based on these findings, SVP has antioxidant action and it protects endothelium.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/27827
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Yang, Fang,Suo, Yourui,Chen, Dongli,et al. Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia[J]. BIOSCIENCE TRENDS,2016.
APA	Yang, Fang,Suo, Yourui,Chen, Dongli,&Tong, Li.(2016).Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia.BIOSCIENCE TRENDS.
MLA	Yang, Fang,et al."Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia".BIOSCIENCE TRENDS (2016).