Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.

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	Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.
	Gao, Tingting ; Ma, Shuai ; Song, Jiayin ; Bi, Hongtao ; Tao, Yanduo
	2011-11-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES ; Gao, TT; Ma, S; Song, JY; Bi, HT; Tao, YD.Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.,INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2011,49(4):580-586
摘要	Aconitum kusnezoffii Reichb., one of the earliest recorded toxic species of genus Aconitum, has been used as traditional Chinese medicine and medicinal diet over the last 2500 years to treat heart failure congestion, neuralgia, rheumatism and gout, etc. In the present paper, four water-soluble polysaccharide fractions isolated from the tubers of A. kusnezoffii Reichb. were studied the antioxidant and immunological activities for the first time. In vitro antioxidant assays indicated that fraction WKCP-A had noticeable scavenging activities on DPPH radical, hydroxyl radical, superoxide anion, H(2)O(2) and self-oxidation of 1,2,3-phentriol, ferrous ion-chelating ability and reducing power. Moreover, the in vivo immunological assay exhibited that fractions WKCP-A and WKHP could more significantly enhance splenic lymphocyte proliferation and macrophage phagocytosis than other fractions. Therefore, the water-soluble polysaccharides from A. kusnezoffii Reichb., especially WKCP-A, have the potential to be explored as novel natural antioxidants and immunostimulating agents for using in functional foods or medicine. (C) 2011 Elsevier B.V. All rights reserved.; Aconitum kusnezoffii Reichb., one of the earliest recorded toxic species of genus Aconitum, has been used as traditional Chinese medicine and medicinal diet over the last 2500 years to treat heart failure congestion, neuralgia, rheumatism and gout, etc. In the present paper, four water-soluble polysaccharide fractions isolated from the tubers of A. kusnezoffii Reichb. were studied the antioxidant and immunological activities for the first time. In vitro antioxidant assays indicated that fraction WKCP-A had noticeable scavenging activities on DPPH radical, hydroxyl radical, superoxide anion, H2O2 and self-oxidation of 1,2,3-phentriol, ferrous ion-chelating ability and reducing power. Moreover, the in vivo immunological assay exhibited that fractions WKCP-A and WKHP could more significantly enhance splenic lymphocyte proliferation and macrophage phagocytosis than other fractions. Therefore, the water-soluble polysaccharides from A. kusnezoffii Reichb., especially WKCP-A, have the potential to be explored as novel natural antioxidants and immunostimulating agents for using in functional foods or medicine. (C) 2011 Elsevier B.V. All rights reserved.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/30619
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Gao, Tingting,Ma, Shuai,Song, Jiayin,et al. Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, Gao, TT; Ma, S; Song, JY; Bi, HT; Tao, YD.Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.,INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2011,49(4):580-586,2011.
APA	Gao, Tingting,Ma, Shuai,Song, Jiayin,Bi, Hongtao,&Tao, Yanduo.(2011).Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb..INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.
MLA	Gao, Tingting,et al."Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2011).