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同位素编码衍生-分散液液微萃取/超高效液相色谱-串联质谱检测大鼠脑微透析液中儿茶酚胺
亓伟梅 ; 赵先恩 ; 亓永 ; 孙志伟 ; 陈光 ; 尤进茂 ; 索有瑞
2015
Source Publication分析测试学报
Abstract为实现微量大鼠脑微透析液中3种儿茶酚胺化合物的高灵敏检测,采用d0/d3-10-甲基-吖啶酮-2-磺酰氯(d0/d3-MASC)为同位素编码衍生化试剂,联合使用超声辅助分散液液微萃取技术,建立了超高效液相色谱-串联质谱(UHPLC-MS/MS)快速测定多巴胺(DA)、肾上腺素(EP)和去甲肾上腺素(NE)的分析方法。分别以d0-MASC和d3-MASC衍生微透析液样品和对照品,混合后采用分散液液微萃取技术富集净化,再进行UHPLC-MS/MS检测,以d3-MASC衍生物作为相应d0-MASC衍生物的内标物进行定量。结果表明,在p H 10.8乙腈水溶液中于37℃衍生反应3 min,即可实现待测...
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/32397
Collection中国科学院西北高原生物研究所
Recommended Citation
GB/T 7714
亓伟梅,赵先恩,亓永,等. 同位素编码衍生-分散液液微萃取/超高效液相色谱-串联质谱检测大鼠脑微透析液中儿茶酚胺[J]. 分析测试学报,2015.
APA 亓伟梅.,赵先恩.,亓永.,孙志伟.,陈光.,...&索有瑞.(2015).同位素编码衍生-分散液液微萃取/超高效液相色谱-串联质谱检测大鼠脑微透析液中儿茶酚胺.分析测试学报.
MLA 亓伟梅,et al."同位素编码衍生-分散液液微萃取/超高效液相色谱-串联质谱检测大鼠脑微透析液中儿茶酚胺".分析测试学报 (2015).
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