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Photoinduced electron transfer from polymer-templated Ag nanoclusters to G-quadruplex-hemin complexes for the construction of versatile biosensors and logic gate applications
Qu, Fei ; Mao, Beibei ; Xue, Fangfang ; Xia, Lian ; You, Jinmao ; Song, Cuihua
2018-03-01
Source PublicationANALYTICAL AND BIOANALYTICAL CHEMISTRY
AbstractIn this paper, fluorescent Ag nanoclusters (Ag NCs) templated by hyperbranched polyethyleneimine (PEI) are utilized as a versatile probe through the photoinduced electron transfer (PET) between PEI-Ag NCs and G-quadruplex-hemin complexes. In the presence of hemin and target molecule, the specific conjugation with its aptamer induces the conformational change of the DNA sequence, releasing the G-quadruplex sequence part. Once the G-quadruplex-hemin complexes are introduced, electron transfer from the PEI-Ag NCs to G-quadruplex-hemin complexes occurs, resulting in fluorescence quenching. Through changing the sensing DNA sequence, this novel PET system enables the specific detection of target DNA and adenosine triphosphate (ATP) with the wide linear range of 1-200 nM and 5-500 nM, respectively, and the corresponding limit of detection as low as 0.3 nM for target DNA and 1.5 nM for ATP. In addition, the proposed method is successfully applied to the determination of ATP in human serum samples with satisfactory recoveries, and a logic gate is fabricated using target molecules and hemin as inputs and the fluorescence signal of PEI-Ag NCs as an output.
Document Type期刊论文
Identifierhttp://210.75.249.4/handle/363003/34003
Collection中国科学院西北高原生物研究所
Recommended Citation
GB/T 7714
Qu, Fei,Mao, Beibei,Xue, Fangfang,et al. Photoinduced electron transfer from polymer-templated Ag nanoclusters to G-quadruplex-hemin complexes for the construction of versatile biosensors and logic gate applications[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2018.
APA Qu, Fei,Mao, Beibei,Xue, Fangfang,Xia, Lian,You, Jinmao,&Song, Cuihua.(2018).Photoinduced electron transfer from polymer-templated Ag nanoclusters to G-quadruplex-hemin complexes for the construction of versatile biosensors and logic gate applications.ANALYTICAL AND BIOANALYTICAL CHEMISTRY.
MLA Qu, Fei,et al."Photoinduced electron transfer from polymer-templated Ag nanoclusters to G-quadruplex-hemin complexes for the construction of versatile biosensors and logic gate applications".ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2018).
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