Predicted structural change in erythropoietin of plateau zokors - Adaptation to high altitude

NWIPB OpenIR

	Predicted structural change in erythropoietin of plateau zokors - Adaptation to high altitude
	Wang, Zhenlong 2; Zhang, Yanming 1
	2012-06-15
发表期刊	GENE
ISSN	0378-1119
卷号	501 期号:2 页码:206-212
文章类型	Article
摘要	Erythropoietin (EPO) is a glycoprotein hormone, expressed mainly in fetus liver and adult kidneys. EPO plays an important role in enhancing red blood cell formation in bone marrow under hypoxia. Plateau zokor (Myospalax baileyi), an subterranean burrowing endemic rodent inhabiting areas of 2 800-4 200 m above sea level on Qinghai-Tibet Plateau, is a typical high hypoxia tolerant mammal with high ratio of oxygen utilization in adaptation to the harsh plateau environment. To investigate the possible mechanisms of adaptation of plateau zokor EPO to high altitude, the complete cDNA and amino acid sequences of plateau zokor EPO have been described. Phylogenetic tree of Epo showed the convergence of the Spalax and Myospalax, indicating that, the convergent evolution was driven by similar hypoxic ecological niches. Our results showed that some common sites under positive selection in zokor (116M and 144A) and Spalax (102R, 116M, 144A and 152P) are the important sites for Epo biological activity. This study thus reports a gene level observation which may be involved in adaptation to underground life at high altitude. (C) 2012 Elsevier B.V. All rights reserved.; Erythropoietin (EPO) is a glycoprotein hormone, expressed mainly in fetus liver and adult kidneys. EPO plays an important role in enhancing red blood cell formation in bone marrow under hypoxia. Plateau zokor (Myospalax baileyi), an subterranean burrowing endemic rodent inhabiting areas of 2 800-4 200 m above sea level on Qinghai-Tibet Plateau, is a typical high hypoxia tolerant mammal with high ratio of oxygen utilization in adaptation to the harsh plateau environment. To investigate the possible mechanisms of adaptation of plateau zokor EPO to high altitude, the complete cDNA and amino acid sequences of plateau zokor EPO have been described. Phylogenetic tree of Epo showed the convergence of the Spalax and Myospalax, indicating that, the convergent evolution was driven by similar hypoxic ecological niches. Our results showed that some common sites under positive selection in zokor (116M and 144A) and Spalax (102R, 116M, 144A and 152P) are the important sites for Epo biological activity. This study thus reports a gene level observation which may be involved in adaptation to underground life at high altitude. (C) 2012 Elsevier B.V. All rights reserved.
关键词	Qinghai-tibet Plateau Plateau Zokor Erythropoietin Cdna Cloning
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	AMINO-ACID SITES ; CODON-SUBSTITUTION MODELS ; MYOSPALAX-FONTANIERII ; TRANSCRIPTION FACTORS ; OCHOTONA-CURZONIAE ; POSITIVE SELECTION ; GENE-EXPRESSION ; ALPINE MEADOW ; LIKELIHOOD ; SEQUENCES
收录类别	SCI
语种	英语
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000304730800014
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/3658
专题	中国科学院西北高原生物研究所
作者单位	1.Chinese Acad Sci, Key Lab Adaptat & Evolut Plateau Biota, NW Plateau Inst Biol, Xining 810001, Peoples R China 2.Zhengzhou Univ, Dept Bioengn, Zhengzhou 450001, Hennan, Peoples R China
推荐引用方式 GB/T 7714	Wang, Zhenlong,Zhang, Yanming. Predicted structural change in erythropoietin of plateau zokors - Adaptation to high altitude[J]. GENE,2012,501(2):206-212.
APA	Wang, Zhenlong,&Zhang, Yanming.(2012).Predicted structural change in erythropoietin of plateau zokors - Adaptation to high altitude.GENE,501(2),206-212.
MLA	Wang, Zhenlong,et al."Predicted structural change in erythropoietin of plateau zokors - Adaptation to high altitude".GENE 501.2(2012):206-212.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Predicted structural（824KB）			开放获取	--	浏览下载