The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice

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	The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice
	Wu, Qin ; Li, Wen-Kai ; Zhou, Zheng-Ping ; Li, Ying-Ying ; Xiong, Ting-Wan ; Du, Yi-Zhi ; Wei, Li-Xin ; Liu, Jie
	2016-07-01
发表期刊	REGULATORY TOXICOLOGY AND PHARMACOLOGY
摘要	Zuotai is composed mainly of beta-HgS, while cinnabar mainly contains alpha-HgS. Both forms of HgS are used in traditional medicines and their safety is of concern. This study aimed to compare the hepatotoxicity potential of Zuotai and alpha-HgS with mercury chloride (HgCl2) and methylmercury (MeHg) in mice. Mice were orally administrated with Zuotai (30 mg/kg), alpha-HgS (HgS, 30 mg/kg), HgCl2 (33.6 mg/kg), or CH3HgCl (3.1 mg/kg) for 7 days, and liver injury and gene expressions related to toxicity, inflammation and Nrf2 were examined. Animal body weights were decreased by HgCl2 and to a less extent by MeHg. HgCl2 and MeHg produced spotted hepatocyte swelling and inflammation, while such lesions are mild in Zuotai and HgS-treated mice. Liver Hg contents reached 45-70 ng/mg in HgCl2 and MeHg groups; but only 1-2 ng/mg in Zuotai and HgS groups. HgCl2 and MeHg increased the expression of liver injury biomarker genes metallothionein-1 (MT-1) and heme oxygenase-1 (HO-1); the inflammation biomarkers early growth response gene (Egr1), glutathione S-transferase (Gst-mu), chemokine (mKC) and microphage inflammatory protein (MIP-2), while these changes were insignificant in Zuotai and HgS groups. However, all mercury compounds were able to increase the Nrf2 pathway genes NAD(P)H:quinone oxidoreductase 1 (Nqo1) and Glutamate-cysteine ligase, catalytic subunit (Gclc). In conclusion, the Ti-betan medicine Zuotai and HgS are less hepatotoxic than HgCl2 and MeHg, and differ from HgCl2 and MeHg in hepatic Hg accumulation and toxicological responses. (C) 2016 Elsevier Inc. All rights reserved.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/37809
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Wu, Qin,Li, Wen-Kai,Zhou, Zheng-Ping,et al. The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY,2016.
APA	Wu, Qin.,Li, Wen-Kai.,Zhou, Zheng-Ping.,Li, Ying-Ying.,Xiong, Ting-Wan.,...&Liu, Jie.(2016).The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice.REGULATORY TOXICOLOGY AND PHARMACOLOGY.
MLA	Wu, Qin,et al."The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice".REGULATORY TOXICOLOGY AND PHARMACOLOGY (2016).