Knowledge Management System of Northwest Institute of Plateau Biology, CAS
| Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau | |
| Zhao, Yang1,2; Ren, Ji-Long1; Wang, Ming-Yang1,2; Zhang, Sheng-Ting1,2; Liu, Yu1; Li, Min1,2; Cao, Yi-Bin1,3; Zu, Hu-Yue1; Chen, Xiao-Cheng4; Wu, Chung-I5,6; Nevo, Eviatar7,8; Chen, Xue-Qun1,2,9; Du, Ji-Zeng1,2,9; Du, JZ (reprint author), Zhejiang Univ, Sch Med, Dept Basic Med Sci, Div Neurobiol & Physiol, Hangzhou 310058, Zhejiang, Peoples R China. | |
| 2013-12-17 | |
| 发表期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| ISSN | 0027-8424 |
| 卷号 | 110期号:51页码:20639-20644 |
| 文章类型 | Article |
| 摘要 | Mutational changes in p53 correlate well with tumorigenesis. Remarkably, however, relatively little is known about the role that p53 variations may play in environmental adaptation. Here we report that codon asparagine-104 (104N) and glutamic acid-104 (104E), respectively, of the p53 gene in the wild zokor (Myospalax baileyi) and root vole (Microtus oeconomus) are adaptively variable, meeting the environmental stresses of the Tibetan plateau. They differ from serine-104 (104S) seen in other rodents, including the lowland subterranean zokor Myospalax cansus, and from serine 106 (106S) in humans. Based on site-directed mutational analysis in human cell lines, the codon 104N variation in M. baileyi is responsible for the adaptive balance of the transactivation of apoptotic genes under hypoxia, cold, and acidic stresses. The 104E p53 variant in Microtus oeconomus suppresses apoptotic gene transactivation and cell apoptosis. Neither 104N nor 104E affects the cell-cycle genes. We propose that these variations in p53 codon 104 are an outcome of environmental adaptation and evolutionary selection that enhance cellular strategies for surviving the environmental stresses of hypoxia and cold (in M. baileyi and M. oeconomus) and hypercapnia (in M. baileyi) in the stressful environments of the Qinghai-Tibet plateau.; Mutational changes in p53 correlate well with tumorigenesis. Remarkably, however, relatively little is known about the role that p53 variations may play in environmental adaptation. Here we report that codon asparagine-104 (104N) and glutamic acid-104 (104E), respectively, of the p53 gene in the wild zokor (Myospalax baileyi) and root vole (Microtus oeconomus) are adaptively variable, meeting the environmental stresses of the Tibetan plateau. They differ from serine-104 (104S) seen in other rodents, including the lowland subterranean zokor Myospalax cansus, and from serine 106 (106S) in humans. Based on site-directed mutational analysis in human cell lines, the codon 104N variation in M. baileyi is responsible for the adaptive balance of the transactivation of apoptotic genes under hypoxia, cold, and acidic stresses. The 104E p53 variant in Microtus oeconomus suppresses apoptotic gene transactivation and cell apoptosis. Neither 104N nor 104E affects the cell-cycle genes. We propose that these variations in p53 codon 104 are an outcome of environmental adaptation and evolutionary selection that enhance cellular strategies for surviving the environmental stresses of hypoxia and cold (in M. baileyi and M. oeconomus) and hypercapnia (in M. baileyi) in the stressful environments of the Qinghai-Tibet plateau. |
| 关键词 | Ecological Stress Evolution Apaf1 Noxa Puma |
| WOS标题词 | Science & Technology |
| 关键词[WOS] | P53-MEDIATED TRANSCRIPTIONAL REPRESSION ; FLOUNDER PLATICHTHYS-FLESUS ; VOLE MICROTUS-OECONOMUS ; MASTER REGULATOR P53 ; WILD-TYPE P53 ; POSITIVE SELECTION ; GROWTH-FACTORS ; HYPOXIA ; QINGHAI ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000328548600067 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://210.75.249.4/handle/363003/3887 |
| 专题 | 中国科学院西北高原生物研究所 |
| 通讯作者 | Du, JZ (reprint author), Zhejiang Univ, Sch Med, Dept Basic Med Sci, Div Neurobiol & Physiol, Hangzhou 310058, Zhejiang, Peoples R China. |
| 作者单位 | 1.Zhejiang Univ, Sch Med, Dept Basic Med Sci, Div Neurobiol & Physiol, Hangzhou 310058, Zhejiang, Peoples R China 2.Minist Hlth, Key Lab Med Neurobiol, Hangzhou 310058, Zhejiang, Peoples R China 3.Zhejiang Normal Univ, Coll Chem & Life Sci, Dept Biotechnol, Div Biochem & Mol Biol, Jinhua 321004, Peoples R China 4.Chinese Acad Sci, Northwest Plateau Inst Biol, Xining 810001, Peoples R China 5.Chinese Acad Sci, Beijing Inst Genom, Beijing 101300, Peoples R China 6.Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA 7.Univ Haifa, Inst Evolut, IL-31905 Haifa, Israel 8.Univ Haifa, Int Grad Ctr Evolut, IL-31905 Haifa, Israel 9.Key Lab Neurosci Zhejiang Prov, Hangzhou 310058, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yang,Ren, Ji-Long,Wang, Ming-Yang,et al. Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2013,110(51):20639-20644. |
| APA | Zhao, Yang.,Ren, Ji-Long.,Wang, Ming-Yang.,Zhang, Sheng-Ting.,Liu, Yu.,...&Du, JZ .(2013).Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,110(51),20639-20644. |
| MLA | Zhao, Yang,et al."Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110.51(2013):20639-20644. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Codon 104 variation （1356KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论