Antioxidant xanthones from Swertia mussotii, a high altitude plant

doi:10.1016/j.fitote.2013.08.021

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	Antioxidant xanthones from Swertia mussotii, a high altitude plant
	Luo, Cui-Ting 1; Mao, Shuang-Shuang 1; Liu, Fang-Lan 1; Yang, Mao-xun 1; Chen, Heru 1,2,3; Kurihara, Hiroshi 1,3; Li, Yulin 4; Chen, HR (reprint author), Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Huangpu Ave West 601, Guangzhou 510632, Guangdong, Peoples R China.
	2013-12-01
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	91 页码:140-147
文章类型	Article
摘要	Four new xanthones, 3,5,6,8-tetrahydroxyxanthone-1-C-beta-D-glucoside (1), 7-hydroxy-3,4,8-trimethoxyxanthone-1-O-(beta-D-glucoside) (2), 6-hydroxy-3,5-dimethoxyxanthone-1-O-(beta-D-glucoside) (3), 3,4,7,8-tetramethoxyxanthone-1-O-(beta-D-glucoside) (4), together with twenty-one known xanthones (5-25) were isolated from the ethanol aqueous extract of Swertia mussotii. Their structures were elucidated via spectroscopic analyses. Oxygen radical absorbance capacity of all the isolated xanthones was systematically evaluated by ORAC(FL) assay. Results disclose that all the tested xanthones display moderate to excellent antioxidant activity, where I is the most active compound and 13 is the least one. A preliminary structure-activity relationship is also discussed. (C) 2013 Elsevier B.V. All rights reserved.; Four new xanthones, 3,5,6,8-tetrahydroxyxanthone-1-C-beta-D-glucoside (1), 7-hydroxy-3,4,8-trimethoxyxanthone-1-O-(beta-D-glucoside) (2), 6-hydroxy-3,5-dimethoxyxanthone-1-O-(beta-D-glucoside) (3), 3,4,7,8-tetramethoxyxanthone-1-O-(beta-D-glucoside) (4), together with twenty-one known xanthones (5-25) were isolated from the ethanol aqueous extract of Swertia mussotii. Their structures were elucidated via spectroscopic analyses. Oxygen radical absorbance capacity of all the isolated xanthones was systematically evaluated by ORAC(FL) assay. Results disclose that all the tested xanthones display moderate to excellent antioxidant activity, where I is the most active compound and 13 is the least one. A preliminary structure-activity relationship is also discussed. (C) 2013 Elsevier B.V. All rights reserved.
关键词	Swertia L. Swertia Mussotii Xanthones Antioxidant Orac
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.fitote.2013.08.021
关键词[WOS]	GARCINIA-MANGOSTANA ; MEDICINE ; FRANCH ; CONSTITUENTS ; GENTIANACEAE ; METABOLITES ; MANGIFERIN ; CELLS
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81172982) ; Guangdong Provincial Project of Science and Technology(2010A030100006) ; State Key Laboratory of Drug Research(SIMM1302KF-12)
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000327574300020
引用统计	被引频次：30[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/3894
专题	中国科学院西北高原生物研究所
通讯作者	Chen, HR (reprint author), Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Huangpu Ave West 601, Guangzhou 510632, Guangdong, Peoples R China.
作者单位	1.Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China 4.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810001, Peoples R China
推荐引用方式 GB/T 7714	Luo, Cui-Ting,Mao, Shuang-Shuang,Liu, Fang-Lan,et al. Antioxidant xanthones from Swertia mussotii, a high altitude plant[J]. FITOTERAPIA,2013,91:140-147.
APA	Luo, Cui-Ting.,Mao, Shuang-Shuang.,Liu, Fang-Lan.,Yang, Mao-xun.,Chen, Heru.,...&Chen, HR .(2013).Antioxidant xanthones from Swertia mussotii, a high altitude plant.FITOTERAPIA,91,140-147.
MLA	Luo, Cui-Ting,et al."Antioxidant xanthones from Swertia mussotii, a high altitude plant".FITOTERAPIA 91(2013):140-147.

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