Knowledge Management System of Northwest Institute of Plateau Biology, CAS
Anti-proliferative Activities of Two Flavonols with Unsubstituted B-ring from the Leaves of Platanus acerifolia | |
Chen, Hui-Feng ; Huang, Ri-Zhen ; Zuo, Bo ; Ji, Lan-Ju ; Mo, Zhi-Jian ; Liao, Zhi-Xin | |
2017-11-01 | |
发表期刊 | NATURAL PRODUCT COMMUNICATIONS
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摘要 | The anti-proliferative activities against five cancer cell lines of two flavonols (1, 2) with unsubstituted B ring isolated from the ethanol extract of the leaves of Platanus acerifolia were investigated. The results showed that compound 1 possessed a noteworthy anti-proliferative activity against MGC-803 cells with an IC50 value of 17.26 +/- 1.04 mu M, and compound 2 was less active than 1 with an IC50 value of 20.29 +/- 1.37 mu M compared with 41.94 +/- 1.58 mu M for the positive control group. In addition, the results of Hoechst 33258 staining, AO/EB staining and annexinV-FITC assays indicated that 1 caused a significant MGC-803 cellular apoptosis in a dose-dependent manner. The further mechanisms showed that compound 1 induced the production of ROS, decreased the mitochondrial membrane potential, and altered pro- and anti-apoptotic proteins, leading to activation of caspase-9 and caspase-3 in the process of cellular apoptosis. The present investigation indicated that compound 1 could be used as a potential anti-cancer candidate. |
出版者 | NATURAL PRODUCTS INC |
文献类型 | 期刊论文 |
条目标识符 | http://210.75.249.4/handle/363003/39049 |
专题 | 中国科学院西北高原生物研究所 |
推荐引用方式 GB/T 7714 | Chen, Hui-Feng,Huang, Ri-Zhen,Zuo, Bo,et al. Anti-proliferative Activities of Two Flavonols with Unsubstituted B-ring from the Leaves of Platanus acerifolia[J]. NATURAL PRODUCT COMMUNICATIONS,2017. |
APA | Chen, Hui-Feng,Huang, Ri-Zhen,Zuo, Bo,Ji, Lan-Ju,Mo, Zhi-Jian,&Liao, Zhi-Xin.(2017).Anti-proliferative Activities of Two Flavonols with Unsubstituted B-ring from the Leaves of Platanus acerifolia.NATURAL PRODUCT COMMUNICATIONS. |
MLA | Chen, Hui-Feng,et al."Anti-proliferative Activities of Two Flavonols with Unsubstituted B-ring from the Leaves of Platanus acerifolia".NATURAL PRODUCT COMMUNICATIONS (2017). |
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