Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice

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	Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice
	Wang, Hui ; Zhou, Jia ; Liu, Qiong Zhen ; Wang, Lu Lu ; Shang, Jing
	2017-05-24
发表期刊	SCIENTIFIC REPORTS
摘要	High fat diet (HFD)-induced metabolic disorders may lead to emotional disorders. This study aimed to explore the effect of simvastatin (SMV) and bezafibrate (BZ) on improving HFD-induced emotional changes, and tried to identify their different mechanisms. The intraperitoneal glucose tolerance test (IPGTT) was used to evaluate glucose control ability; and behavior tests including open field tests (OFT), forced swimming tests (FST), tail suspension tests (TST) and sucrose preference (SPT), were then performed to evaluate emotional changes. Serum samples were collected for the LC-MS based metabolomics analysis to explore the emotional-related differential compounds; we then evaluated the effect of the drugs. The abnormal serum metabolic profiling and emotional changes caused by HFD in mice was alleviated by SMV treatment, whereas BZ only affected the emotional disorder. The improvement of cannabinoid analogues and then produced influences on the endocannabinoid system, which may be a potential mechanism SMV action. BZ promoted tryptophan-serotonin pathway and inhibited tryptophan-kynurenine pathway, which may be its mechanism of action. Here, we proposed a shed light on the biological mechanisms underlying the observed effects, and identified an important drug candidate for the treatment of emotional disorders induced by HFD.
文献类型	期刊论文
条目标识符	http://210.75.249.4/handle/363003/39090
专题	中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Wang, Hui,Zhou, Jia,Liu, Qiong Zhen,et al. Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice[J]. SCIENTIFIC REPORTS,2017.
APA	Wang, Hui,Zhou, Jia,Liu, Qiong Zhen,Wang, Lu Lu,&Shang, Jing.(2017).Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice.SCIENTIFIC REPORTS.
MLA	Wang, Hui,et al."Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice".SCIENTIFIC REPORTS (2017).