NWIPB OpenIR
Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet
Cai, Zhenyuan ; Wang, Liuyang ; Song, Xiaoying ; Tagore, Somnath ; Li, Xiangfeng ; Wang, Huihua ; Chen, Jiarui ; Li, Kexin ; Frenkel, Zeev ; Gao, Dahai ; Frenkel-Morgenstern, Milana ; Zhang, Tongzuo ; Nevo, Eviatar
2018-03-16
发表期刊SCIENTIFIC REPORTS
摘要Animals living at high altitudes have evolved distinct phenotypic and genotypic adaptations against stressful environments. We studied the adaptive patterns of altitudinal stresses on transcriptome turnover in subterranean plateau zokors (Myospalax baileyi) in the high-altitude Qinghai-Tibetan Plateau. Transcriptomes of zokors from three populations with distinct altitudes and ecologies (Low: 2846 m, Middle: 3282 m, High: 3,714 m) were sequenced and compared. Phylogenetic and principal component analyses classified them into three divergent altitudinal population clusters. Genetic polymorphisms showed that the population at H, approaching the uppermost species boundary, harbors the highest genetic polymorphism. Moreover, 1056 highly up-regulated UniGenes were identified from M to H. Gene ontologies reveal genes like EPAS1 and COX1 were overexpressed under hypoxia conditions. EPAS1, EGLN1, and COX1 were convergent in high-altitude adaptation against stresses in other species. The fixation indices (FST and GST)-based outlier analysis identified 191 and 211 genes, highly differentiated among L, M, and H. We observed adaptive transcriptome changes in Myospalax baileyi, across a few hundred meters, near the uppermost species boundary, regardless of their relatively stable underground burrows' microclimate. The highly variant genes identified in Myospalax were involved in hypoxia tolerance, hypercapnia tolerance, ATP-pathway energetics, and temperature changes.
文献类型期刊论文
条目标识符http://210.75.249.4/handle/363003/39115
专题中国科学院西北高原生物研究所
推荐引用方式
GB/T 7714
Cai, Zhenyuan,Wang, Liuyang,Song, Xiaoying,et al. Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet[J]. SCIENTIFIC REPORTS,2018.
APA Cai, Zhenyuan.,Wang, Liuyang.,Song, Xiaoying.,Tagore, Somnath.,Li, Xiangfeng.,...&Nevo, Eviatar.(2018).Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet.SCIENTIFIC REPORTS.
MLA Cai, Zhenyuan,et al."Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet".SCIENTIFIC REPORTS (2018).
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