Knowledge Management System of Northwest Institute of Plateau Biology, CAS
| Optimization of Microwave-Assisted Extraction of Cordycepic Acid and Cordycepin from Cultured Cordyceps militaris by Response Surface Methodology | |
| Deng, Li1,2,3,4; Zhou, Tong-Yong1,2,3; Pi, Li1,2,3; Zhao, Xiao-Hui1,2,3; Han, Tao1,2,3; Li, Yi-Kang1,2,3; Han, Fa1,3; Han, F (reprint author), Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810008, Peoples R China. | |
| 2013-10-01 | |
| 发表期刊 | ASIAN JOURNAL OF CHEMISTRY
 |
| ISSN | 0970-7077 |
| 卷号 | 25期号:14页码:8065-8071 |
| 文章类型 | Article |
| 摘要 | The response surface methodology was employed to optimize the integrated extraction parameters of cordycepic acid and cordycepin from cultured Cordyceps militaris (L.) link based on a single-factor experiment. The Box-Behnken design with three independent variables i.e., microwave power (W), water/material ratio (mL/g) and extraction time (min) was used. The experimental data obtained were fitted to a second-order polynomial equation using multiple regression analysis. The three-dimensional response surface plot and contour plot derived from the mathematical models were applied to determine the optimal conditions. The optimum extraction condition was obtained as follows: microwave-assisted extraction, microwave power of 649.33 W, extraction time of 5.74 min, water/material ratio of 38. 99 mL/g and extraction number of three. The yield of cordycepic acid and cordycepin were 2.47 and 0.79 %, respectively. Under these conditions, the experimental values of 3.12 and 0.75 % well agreed with those predicted by the model.; The response surface methodology was employed to optimize the integrated extraction parameters of cordycepic acid and cordycepin from cultured Cordyceps militaris (L.) link based on a single-factor experiment. The Box-Behnken design with three independent variables i.e., microwave power (W), water/material ratio (mL/g) and extraction time (min) was used. The experimental data obtained were fitted to a second-order polynomial equation using multiple regression analysis. The three-dimensional response surface plot and contour plot derived from the mathematical models were applied to determine the optimal conditions. The optimum extraction condition was obtained as follows: microwave-assisted extraction, microwave power of 649.33 W, extraction time of 5.74 min, water/material ratio of 38. 99 mL/g and extraction number of three. The yield of cordycepic acid and cordycepin were 2.47 and 0.79 %, respectively. Under these conditions, the experimental values of 3.12 and 0.75 % well agreed with those predicted by the model. |
| 关键词 | Cordyceps Militaris Cordycepin Cordycepic Acid Microwave-assisted Extraction Reponse Surface Methodology |
| WOS标题词 | Science & Technology ; Physical Sciences |
| DOI | 10.14233/ajchem.2013.15056 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| WOS记录号 | WOS:000325096400094 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://210.75.249.4/handle/363003/3917 |
| 专题 | 中国科学院西北高原生物研究所 |
| 通讯作者 | Han, F (reprint author), Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810008, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810008, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810008, Peoples R China 4.Chinese Acad Sci, Northwest Inst Plateau Biol, Huzhou Plateau Biol Resource Ctr Innovat, Huzhou 310001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Li,Zhou, Tong-Yong,Pi, Li,et al. Optimization of Microwave-Assisted Extraction of Cordycepic Acid and Cordycepin from Cultured Cordyceps militaris by Response Surface Methodology[J]. ASIAN JOURNAL OF CHEMISTRY,2013,25(14):8065-8071. |
| APA | Deng, Li.,Zhou, Tong-Yong.,Pi, Li.,Zhao, Xiao-Hui.,Han, Tao.,...&Han, F .(2013).Optimization of Microwave-Assisted Extraction of Cordycepic Acid and Cordycepin from Cultured Cordyceps militaris by Response Surface Methodology.ASIAN JOURNAL OF CHEMISTRY,25(14),8065-8071. |
| MLA | Deng, Li,et al."Optimization of Microwave-Assisted Extraction of Cordycepic Acid and Cordycepin from Cultured Cordyceps militaris by Response Surface Methodology".ASIAN JOURNAL OF CHEMISTRY 25.14(2013):8065-8071. |
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